Neue Marker für NASH bei Typ-2-Diabetes und Adipositas

Zusammenfassung

Die nichtalkoholische Fettleber (NAFL) und nichtalkoholische Steatohepatitis (NASH) sind nicht nur Risikofaktoren für Leberfibrose, Leberzirrhose und das hepatozelluläre Karzinom, sondern sie sind auch stark mit Insulinresistenz, Typ-2-Diabetes und Atherosklerose assoziiert. Darüber hinaus sagt eine Fettleber die Erkrankungswahrscheinlichkeit für Typ-2-Diabetes und Atherosklerose voraus, was eine kausale Rolle der Fettleber in der Pathogenese dieser Erkrankungen impliziert. Folgerichtig zielen Strategien zur Prävention und Therapie der Fettleber darauf hin, frühzeitig zu handeln. Dabei ist zu beachten, dass nicht nur eine genaue und frühzeitige Diagnose einer Fettleber gestellt wird, wie sie es zur Zeit nichtinvasiv mittels der Protonen-Magnetresonz-Spektroskopie möglich ist, sondern auch der NASH, der malignen Form der Fettleber.

Summary

Nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH) are not only risc factors for liver fibrosis, liver cirrhosis and hepatocellular carcinoma, but are also strongly associated with insulin resistance, type 2 diabetes, and atherosclerosis. In addition fatty liver predicts incident type 2 diabetes and atherosclerosis, indicating a causal role of fatty liver in the pathogenesis of these diseases. Consequently strategies aiming at early preventing and treating fatty liver, need to be implemented. In this respect it is important not only to early and precisely diagnose fatty liver, as can be done using non-invasive protone magnetic resonance spectroscopy, but also to diagnose NASH, the malignant form of fatty liver.

Schlüsselwörter

Nichtalkoholische Fettleber (NAFL) - nichtalkoholische Steatohepatitis (NASH) - Typ-2-Diabetes - Atherosklerose - Fetuin-A - Sex Hormone-Binding Globuline

Keywords

Nonalcoholic fatty liver (NAFL) - nonalcoholic steatohepatitis (NASH) - type 2 diabetes - atherosclerosis - Fetuin-A - Sex Hormone-Binding Globuline

^* Heisenberg-Stipendiat der Deutschen Forschungsgemeinschaft

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