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Kinder- und Jugendmedizin 2005; 5(04): 193-196
DOI: 10.1055/s-0037-1617863
Diabetes
Schattauer GmbH

Diabetes mellitus Typ 1 und Zöliakie

Diabetes mellitus type 1 and celiac disease
Birgit Rami
1   Universitätsklinik für Kinder- und Jugendheilkunde Wien (Vorstand: o. Univ.-Prof. Dr. med. Arnold Pollak)
,
Edith Schober
1   Universitätsklinik für Kinder- und Jugendheilkunde Wien (Vorstand: o. Univ.-Prof. Dr. med. Arnold Pollak)
› Author Affiliations
Further Information

Publication History

Eingegangen: 03 April 2005

angenommen: 25 April 2005

Publication Date:
11 January 2018 (online)

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Zusammenfassung

Die Prävalenz der Zöliakie ist bei Kindern und Jugendlichen mit Diabetes mellitus Typ 1 höher als in der Normalbevölkerung. Meistens liegt eine atypische oder silente Form der Zöliakie vor. Die beiden Erkrankungen sind assoziiert, es sind Autoimmunerkrankungen mit einem gemeinsamen genetischen Hintergrund. Weiters nehmen die Prävalenz der Zöliakie sowie die Inzidenz des Diabetes mellitus Typ 1 laufend zu. Die meisten diabetischen Patienten mit Zöliakie werden erst durch ein gezieltes Screening mittels Antikörper entdeckt und es sind eher jüngere Patienten betroffen. Der Goldstandard der Zöliakie-Therapie ist nach wie vor eine lebenslange glutenfreie Diät. Widersprüchliche Ansichten bestehen über den klinischen Benefit einer frühzeitigen Diagnose der silenten Zöliakie durch Screening von Patienten mit Diabetes mellitus Typ 1 und frühzeitiger Therapie mit einer glutenfreien Diät bei diesen Patienten.

Eine klare Aussage, ob die glutenfreie Diät in diesen Fällen einen Einfluss auf die Längen- und Gewichtsentwicklung bzw. die metabolische Kontrolle hat, ist derzeit noch unklar.

Summary

Celiac disease is more prevalent in individuals with diabetes mellitus type 1 than in the normal population. It often presents in an atypical or silent form. Both diseases are associated; both are autoimmune disorders with a common genetic background. The prevalence of celiac disease is constantly increasing, as well as the incidence of diabetes mellitus type 1. Most of the diabetic patients with celiac disease are diagnosed via antibody-specific screening methods and mostly younger patients are affected. The gold standard of celiac therapy is a gluten free diet. Controversy exists concerning the benefit of an early diagnosis of silent forms of celiac disease via screening of diabetic patients and early therapy with gluten free diet in these patients. A clear answer, whether a gluten free diet in these cases has an influence on growth- and weight-development, or their metabolic control, is still missing.

Schlüsselwörter

Diabetes mellitus Typ 1 - Zöliakie - glutenfreie Diät - Autoimmunerkrankung - Screening

Keywords

Diabetes mellitus type 1 - celiac disease - autoimmune disease - gluten free diet - screening
 

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