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Semin Respir Crit Care Med 2018; 39(02): 227-254
DOI: 10.1055/s-0037-1617443
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Fungal Infections Complicating Lung Transplantation

Nina M. Clark
1   Division of Infectious Diseases, Department of Medicine, Loyola University Medical Center, Maywood, Illinois
,
S. Samuel Weigt
2   Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, Department of Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California
,
Michael C. Fishbein
3   Department of Pathology and Laboratory Medicine, The David Geffen School of Medicine at UCL, Los Angeles, California
,
Bernard Kubak
4   Division of Infectious Diseases, Department of Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California
,
John A. Belperio
2   Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, Department of Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California
,
Joseph P. Lynch III
2   Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, Department of Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California
› Author Affiliations
Further Information

Publication History

Publication Date:
26 March 2018 (online)

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Abstract

Lung transplantation is an increasingly utilized modality for treating advanced lung disease. However, lung transplant recipients (LTRs) experience high rates of infection-related mortality and, compared with other solid organ transplant recipients, are at increased risk of infectious complications given the intensity of immunosuppression employed, the presence of airway abnormalities after surgery and exposure of the allograft to the environment. Fungal infections, particularly mold infections, are problematic after transplantation as they are often associated with limited treatment options and poor outcomes. We describe the non-Candida fungal infections occurring in LTRs, including their epidemiology, clinical features, and treatment.

Keywords

invasive fungal infections - mold - organ transplant - lung transplant - aspergillosis - mucormycosis - fusariosis - scedosporiosis - triazoles