Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00035024.xml
Download PDF
Thromb Haemost 1998; 80(05): 757-762
DOI: 10.1055/s-0037-1615354
DOI: 10.1055/s-0037-1615354
Review Article
FVIII Coagulant Activity and Antigen in Subjects with Ischaemic Heart Disease
Further Information
Publication History
Received
08 May 1998
Accepted after revision
15 July 1998
Publication Date:
07 December 2017 (online)
Summary
Raised factor VIII coagulant activity has been associated with Ischaemic Heart Disease and Myocardial Infarction (MI). We measured FVIII:C and FVIII:Ag levels in 288 white European patients characterised for extent of atheroma by coronary angiography and for a history of MI by WHO criteria, and 313 white European healthy controls. FVIII:Ag levels were higher in patients than controls after adjustment for confounding variables (1.17 IU/ml patients, 1.03 IU/ml controls [p <0.0005]), whereas FVIII:C levels were lower in patients (1.26 IU/ml patients, 1.45 IU/ml controls [p < 0.0005]). FVIII:Ag levels were higher in patients with MI and with angiographic evidence of atheroma than controls. FVIII:Ag levels but not FVIII:C levels were a significant independent risk factor for MI in multivariate analysis (Odds Ratio 2.40 [1.35-4.27] [p = 0.003]). No association of FVIII:Ag or FVIII:C levels and presence or extent of atheroma was found in multivariate analysis. In conclusion, this study found an independent association of FVIII:Ag but not FVIII:C with MI.
-
References
- 1 Antonarakis SE. Molecular Genetics of Coagulation Factor VIII Gene and Hemophilia A. Thromb Haemost 1995; 74: 322-8.
- 2 Wion KL, Kelly D, Summerfield JA, Tuddenham EGD, Lawn RM. Distribution of factor VIII mRNA and antigen in human liver and other tissues. Nature 1985; 317: 726-8.
- 3 Wood WI, Capon DJ, Simonsen CC, Eaton DL, Gitschier J, Keyt B, Seeburg PH, Smith DH, Hollingshead P, Wion KL, Delwart E, Tuddenham EGD, Vehar GA, Lawn RM. Expression of active human factor VIII from recombinant DNA clones. Nature 1984; 312: 330-7.
- 4 Healey JF, Lubin IM, Lollar P. The cDNA and Derived Amino Acid Sequence of Porcine Factor VIII. Blood 1996; 88: 4209-14.
- 5 Zimmerman TS. Factor VIII/von Willebrand Factor. Structure and Function. In: Lusher JM, Mammen EF, McCoy LE, Walz DA. eds. Factor VIII/vWF and Platelet Formation and Function in Health and Disease: A tribute to Marion I, Barnhart. New York:: New York Academy of Sciences; 1987: 53-9.
- 6 Meyer D, Girma JP. Von Willebrand Factor: Structure and Function. Thromb Haemost 1993; 70: 99-104.
- 7 Walker FJ, Fay PJ. Regulation of blood coagulation by the protein C system. FASEB Journal 1992; 6: 2561-7.
- 8 Foster PA, Fulcher CA, Houghten RA, Zimmerman TS. An Immunogenic Region within Residues Val1670-Glu1684 of the Factor VIII Light Chain Induces Antibodies Which Inhibit Binding of Factor VIII to von Willebrand Factor. J Biol Chem 1988; 263: 5230-4.
- 9 Saenko E, Shima M, Rajalakshmi KJ, Scandella D. A Role for the C2 Domain of Factor VIII in Binding to von Willebrand Factor. J Biol Chem 1994; 269: 11601-5.
- 10 Lupu C, Calb M, Ionescu M, Lupu F. Enhanced Prothrombin and Intrinsic Factor X Activation on Blood Platelets from Diabetic Patients. Thromb Haemost 1993; 70: 579-83.
- 11 Cortellaro M, Boschetti C, Cofrancesco E, Zanussi C, Catalano M, de Gaetano G, Gabrielli L, Lombardi B, Specchia G, Tavazzi L, Tremoli E, Della Volpe A, Polli E. and the PLAT Study Group.. The PLAT Study: Hemostatic Function in Relation to Atherothrombotic Ischemic Events in Vascular Disease Patients. Principle Results. Arterioscler Thromb 1992; 12: 1063-70.
- 12 Conlan MG, Folsom AR, Finch A, Davis CE, Sorlie P, Marcucci G, Wu KK. Associations of Factor VIII and von Willebrand Factor with Age, Race, Sex, and Risk Factors for Atherosclerosis. The Atherosclerosis Risk in Communities (ARIC) Study. Thromb Haemost 1993; 70: 380-5.
- 13 Balleisen L, Bailey J, Epping P-H, Schulte H, van de Loo J. Epidemio-logical Study on Factor VII, Factor VIII and Fibrinogen in an Industrial Population: I. Baseline Data on the Relation to Age, Gender, Body-Weight, Smoking, Alcohol, Pill-Using, and Menopause. Thromb Haemost 1985; 54: 475-9.
- 14 Haverkate F, Thompson SG, Duckert F. Haemostasis Factors in Angina Pectoris; Relation to Gender, Age and Acute-phase Reaction. Results of the ECAT Angina Pectoris Study Group. Thromb Haemost 1995; 73: 561-7.
- 15 Ørstavik KH, Magnus P, Reisner H, Berg K, Graham JB, Nance W. Factor VIII and Factor IX in a Twin Population. Evidence for a Major Effect of ABO Locus on Factor VIII Level. Am J Hum Genet 1985; 37: 89-101.
- 16 Catto AJ, Carter A, Barrett J, Bamford J, Grant PJ. von Willebrand Factor and Factor VIII:C in Acute Cerebrovascular Disease: Relationship to stroke subtype and mortality. Thromb Haemost 1997; 77: 1104-8.
- 17 McCallum CJ, Peake IR, Newcombe RG, Bloom AL. Factor VIII Levels and Blood Group Antigens. Thromb Haemost 1983; 50: 757.
- 18 Jeremic M, Weisert O, Gedde-Dahl TW. Factor VIII (AHG) Levels in 1016 Regular Blood Donors. The Effects of Age, Sex, and ABO Blood Groups. Scand J clin Lab Invest 1976; 36: 461-6.
- 19 Preston AE, Barr A. The Plasma Concentration of Factor VIII in the Normal Population. II. The Effects of Age, Sex, and Blood Group. Br J Haematol 1964; 10: 238-45.
- 20 Pearson TA, LaCava J, Weil HFC. Epidemiology of thrombotic-hemostatic factors and their associations with cardiovascular disease. Am J Clin Nutr 1997; 65: 1674S-82S.
- 21 Koster T, Blann AD, Briët E, Vandenbroucke JP, Rosendaal FR. Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis. Lancet 1995; 345: 152-5.
- 22 O’Donnell J, Tuddenham EGD, Manning R, Kemball-Cook G, Johnson D, Laffan M. High Prevalence of Elevated Factor VIII Levels in Patients Referred for Thrombophilia Screening: Role of Increased Synthesis and Relationship to the Acute Phase Reaction. Thromb Haemost 1997; 77: 825-8.
- 23 Folsom AR, Wu KK, Shahar E, Davis CE. for the Atherosclerosis Risk in Communities (ARIC) Study Investigators. Association of Hemostatic Variables With Prevalent Cardiovascular Disease and Asymptomatic Carotid Artery Atherosclerosis. Arterioscler Thromb 1993; 13: 1829-36.
- 24 Pan W-H, Bai C-H, Chen J-R, Chiu H-C. Associations Between Carotid Atherosclerosis and High Factor VIII Activity, Dyslipidemia, and Hyper-tension. Stroke 1997; 28: 88-94.
- 25 Meade TW, North WRS, Chakrabarti R, Stirling Y, Haines AP, Thompson SG, Brozovic M. Haemostatic Function and Cardiovascular Death: Early Results of a Prospective Study. Lancet 1980; 1: 1050-4.
- 26 Meade TW, Cooper JA, Stirling Y, Howarth DJ, Ruddock V, Miller GJ. Factor VIII, ABO blood group and the incidence of ischaemic heart disease. Br J Haematol 1994; 88: 601-7.
- 27 Folsom AR, Wu KK, Rosamond WD, Sharrett AR, Chambless LE. Prospective Study of Hemostatic Factors and Incidence of Coronary Heart Disease. The Atherosclerosis Risk in Communities (ARIC) Study. Circulation 1997; 96: 1102-8.
- 28 Cortellaro M, Boschetti C, Cofrancesco E, Zanussi C, Catalano M, de Gaetano G, Gabrielli L, Lombardi B, Specchia G, Tavazzi L, Tremoli E, Della Volpe A, Polli E. and the PLAT Study Group.. The PLAT Study: a multidisciplinary study of hemostatic function and conventional risk factors in vascular disease patients. Atherosclerosis 1991; 90: 109-18.
- 29 Haines AP, Howarth D, North WRS, Goldenberg E, Stirling Y, Meade TW, Raftery EB, Millar Craig MW. Haemostatic Variables and the Outcome of Myocardial Infarction. Thromb Haemost 1983; 50: 800-3.
- 30 Hamsten A, Blombäck M, Wiman B, Svensson J, Szamosi A, De Faire U, Mettinger L. Haemostatic function in myocardial infarction. Br Heart J 1986; 55: 58-66.
- 31 Meade TW, Mellows S, Brozovic M, Miller GJ, Chakrabarti RR, North WRS, Haines AP, Stirling Y, Imeson JD, Thompson SG. Haemostatic Function and Ischaemic Heart Disease: Principal Results of the Northwick Park Heart Study. Lancet 1986; 2: 533-7.
- 32 Schmitz-Huebner U, Thompson SG, Balleisen L, Fechtrup C, GrosseHeitmeyer W, Kirchhof B, Most E, Müller U-S, Seiffert C, Seiffert D, van de Loo J. Lack of association between haemostatic variables and the presence or the extent of coronary atherosclerosis. Br Heart J 1988; 59: 287-91.
- 33 ECAT Angina Pectoris Study Group.. ECAT anginga pectoris study: baseline associations of haemostatic factors with extent of coronary arteriosclerosis and other coronary risk factors in 3000 patients with angina pectoris undergoing coronary angiography. Eur Heart J 1993; 14: 8-17.
- 34 Thompson SG, Kienast J, Pyke SDM, Haverkate F, van de Loo JCW. for the European Concerted Action on Thrombosis and Disabilities Angina Pectoris Study Group. Hemostatic Factors and the Risk of Myocardial Infarction or Sudden Death in Patients with Angina Pectoris. N Engl J Med 1995; 332: 635-41.
- 35 Rosendaal FR, Varekamp I, Smit C, Vandenbroucke JP, van Dijck H, Hermans J, Suurmeijer TRBM, Briët E. Mortality and causes of death in Dutch haemophiliacs, 1973-86. Br J Haematol 1989; 71: 71-6.
- 36 Triemstra M, Rosendaal FR, Smit C, Van der Ploeg HM, Briët E. Mortality in Patients with Hemophilia. Changes in a Dutch Population from 1986 to 1992 and 1973 to 1986. Ann Intern Med 1995; 123: 823-7.
- 37 Jick H, Slone D, Westerholm B, Inman WHW, Vessey MP, Shapiro S, Lewis GP, Worcester J. Venous Thromboembolic Disease and ABO Blood Type. Lancet 1969; i: 539-42.
- 38 Carter AM, Ossei-Gerning N, Wilson IJ, Grant PJ. Association of the Platelet PlA Polymorphism of Glycoprotein IIb/IIIa and the Fibrinogen Bβ 448 Polymorphism With Myocardial Infarction and Extent of Coronary Artery Disease. Circulation 1997; 96: 1424-31.
- 39 Balleisen L, Assmann G, Bailey J, Epping P-H, Schulte H, van de Loo J. Epidemiological Study on Factor VII, Factor VIII and Fibrinogen in an Industrial Population II Baseline Data on the Relation to Blood Pressure, Blood Glucose, Uric Acid, and Lipid Fractions. Thromb Haemost 1985; 54: 721-3.
- 40 Iso H, Folsom AR, Wu KK, Finch A, Munger RG, Sato S, Shimamoto T, Terao A, Komachi Y. Hemostatic Variables in Japanese and Caucasian Men. Am J Epidemiol 1989; 130: 925-34.
- 41 Lollar P. The Association of Factor VIII With von Willebrand Factor. Mayo Clin Proc 1991; 66: 524-34.
- 42 Millar DS. Phenotype analysis. In: Tuddenham EGD, Cooper DN. eds. The Molecular Genetics of Haemostasis and its Inherited Disorders. Oxford University Press,: 1994: 433-42.