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Thromb Haemost 1999; 82(05): 1412-1416
DOI: 10.1055/s-0037-1614846
DOI: 10.1055/s-0037-1614846
Rapid Communications
Automated Latex Agglutination and ELISA Testing Yield Equivalent D-Dimer Results in Patients with Recent Myocardial Infarction
This work was supported in part by Grant Nos. HL-30616, HL-48259, and HL-07152 from the National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD and by support provided by American Bioproducts Co., Parsippany, NJ.
Further Information
Publication History
Received
24 June 1999
Accepted after revision
15 July 1999
Publication Date:
09 December 2017 (online)
Summary
Our previous prospective study of post-infarction patients described a strong and significant association of increased plasma D-dimer concentrations in those who experienced a subsequent coronary death or non-fatal myocardial infarction. In the present study, we compare results on stored plasma obtained two months after the index myocardial infarction from 1,038 patients of this trial, using a simple automated latex agglutination (LA) assay in parallel with the standard ELISA test. Results show a somewhat higher mean value for the LA assay (702 ± 1092 vs. 638 ± 986 ng/ml, p = 0.0002), a strong linear correlation of the two assays (r = 0.86) and 88% agreement for values below 500 ng/ml by the ELISA test. D-dimer concentrations determined by each assay were highly correlated in patients with subsequent coronary artery events (p = 0.93) and quartile values for both the LA and ELISA were equally predictive of such events (p = 0.003 and p = 0.001, respectively). This is the first demonstration that a latex agglutination assay for D-dimer can be used to assess the prognostic risk of recurrent coronary thrombotic disease after myocardial infarction
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