Effect of Lipid-Lowering Treatment on Factor VII Profile in Hyperlipidemic Patients

Ettore Porreca; Concetta Di Febbo; Concetta Amore; Augusto Di Castelnuovo; Giovanna Baccante; Maria Benedetta Donati; Franco Cuccurullo; Licia Iacoviello

doi:10.1055/s-0037-1614117

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2000; 84(05): 789-793
DOI: 10.1055/s-0037-1614117

Review Article

Schattauer GmbH

Effect of Lipid-Lowering Treatment on Factor VII Profile in Hyperlipidemic Patients

Ettore Porreca

¹Dipartimento di Medicina e Scienze dell’Invecchiamento, Sezione Aterosclerosi e Trombosi, Università “G. D’Annunzio”, Chieti, Italy

,

Concetta Di Febbo

¹Dipartimento di Medicina e Scienze dell’Invecchiamento, Sezione Aterosclerosi e Trombosi, Università “G. D’Annunzio”, Chieti, Italy

,

Concetta Amore

²”Angela Valenti” Laboratory of Genetic and Environmental Risk Factors for Thrombotic Disease Department of Vascular Medicine and Pharmacology Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, S. Maria Imbaro, Chieti, Italy

,

Augusto Di Castelnuovo

²”Angela Valenti” Laboratory of Genetic and Environmental Risk Factors for Thrombotic Disease Department of Vascular Medicine and Pharmacology Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, S. Maria Imbaro, Chieti, Italy

,

Giovanna Baccante

¹Dipartimento di Medicina e Scienze dell’Invecchiamento, Sezione Aterosclerosi e Trombosi, Università “G. D’Annunzio”, Chieti, Italy

,

Maria Benedetta Donati

²”Angela Valenti” Laboratory of Genetic and Environmental Risk Factors for Thrombotic Disease Department of Vascular Medicine and Pharmacology Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, S. Maria Imbaro, Chieti, Italy

,

Franco Cuccurullo

¹Dipartimento di Medicina e Scienze dell’Invecchiamento, Sezione Aterosclerosi e Trombosi, Università “G. D’Annunzio”, Chieti, Italy

,

Licia Iacoviello

²”Angela Valenti” Laboratory of Genetic and Environmental Risk Factors for Thrombotic Disease Department of Vascular Medicine and Pharmacology Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, S. Maria Imbaro, Chieti, Italy

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Abstract

Summary

A link has been suggested between blood lipids and hemostatic activation. Factor VII (FVII) is a coagulation factor which plays a pivotal role in fibrin generation and thrombus formation. Clinical trials have demonstrated that inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase greatly reduce cardiovascular events in patients with and without coronary artery disease but few data, at this time, are available on the effects of lipid-lowering treatment on factor VII levels. We studied thirty-six IIA and IIB type hyperlipidemic patients who, after a preliminary period of lipid-lowering diet, added atorvastatin (20 mg/daily) or continued dietary treatment alone until they achieved LDL-C recommended levels (< 4 mmol/L). Four to six weeks of lipid lowering treatment with diet plus atorvastatin, produced a significant reduction in FVII coagulant activity (FVIIc) and antigen (FVIIAg). No significant changes were observed in activated FVII (FVIIa). The lipid-lowering treatment with diet alone induced an improved lipid pattern, but no significant changes in FVII profile. Our study suggests a significant effect of lipid-lowering treatment on FVII levels. A possibile nonlipid mechanism that modifies FVII pathway may be suggested.

Key words

Factor VII - hyperlipdemia - statins

Volltext

Referenzen

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