Download PDF
Synfacts 2019; 15(03): 0317
DOI: 10.1055/s-0037-1611466
Peptide Chemistry
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Cyclophane-Braced Peptide Macrocycles

Authors

    Contributor(s):

  • Hisashi Yamamoto

  • Takahiro Sawano

Zhang X, Lu G, Sun M, Mahankali M, Ma Y, Zhang M, Hua W, Hu Y, Wang Q, Chen J, He G. * Qi X. * Shen W. * Liu P. * Chen G. * Nankai University, Tianjin and National Institute of Biological Sciences, Beijing, P. R. of China; University of Pittsburgh, California Institute for Biomedical Research, La Jolla, and The Pennsylvania State University, University Park, USA
A General Strategy for Synthesis of Cyclophane-Braced Peptide Macrocycles via Palladium-Catalysed Intramolecular sp3 C–H Arylation.

Nat. Chem. 2018;
10: 540-548
CrossrefPubMedSearch in Google Scholar
Further Information

Publication History

Publication Date:
15 February 2019 (online)

 
 PDF Download Permissions and Reprints

Key words

palladium catalysis - C–H arylation - cyclophanes - macrocycles - peptide macrocycles

Significance

New efficient methods for the intramolecular cyclization of peptides are important in terms of the development of drugs based on cyclic peptides. The authors report a powerful method for constructing new types of peptide macrocycles through palladium-catalyzed, aminoquinoline-­directed, intramolecular C(sp3)–H arylation reactions.


 

Comment

The cyclization of readily accessible linear peptide precursors selectively proceeds at side chains of either aromatic or modified non­aromatic amino acids units to provide a variety of cyclophane-braced peptide macrocycles containing small-sized cyclophanes.


 

 


  Permissions and Reprints