Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2019; 15(03): 0283
DOI: 10.1055/s-0037-1611209
DOI: 10.1055/s-0037-1611209
Polymer-Supported Synthesis
Formal Hydroacylation of Alkynes on Mg3Al–CO3-Layered Double Hydroxide
Further Information
Publication History
Publication Date:
15 February 2019 (online)
Key words
transition-metal-free reaction - layered double hydroxide - hydroacylation - alkynes - aldehydesSignificance
Mg3Al–CO3-layered double hydroxide (Mg3Al–CO3 LDH) catalyzed the formal hydroacylation of terminal arylalkynes with aromatic aldehydes under argon to give the corresponding diaryl α,β-unsaturated ketones in up to 85% yield (24 examples).
#
Comment
In the reaction of phenylacetylene with p-anisaldehyde, Mg3Al–CO3 LDH was recovered and reused three times with a slight loss of its catalytic activity (fresh: 91% yield; third reuse: 73% yield).
#
#