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Synfacts 2018; 14(07): 0761
DOI: 10.1055/s-0037-1610064
DOI: 10.1055/s-0037-1610064
Polymer-Supported Synthesis
Continuous-Flow Pd/C-Catalyzed Reductive Alkylation of Alcohols with Aldehydes
Bruniaux S.
Luart D.
Len C.
* Université de Technologie de Compiègne, Ecole Supérieure de Chimie Organique et Minérale, Compiègne, and PSL Research University, Paris, France
Continuous-Flow Reductive Alkylation: Synthesis of Bio-Based Symmetrical and Dissymmetrical Ethers.
Synthesis 2018;
50: 1849-1856
Continuous-Flow Reductive Alkylation: Synthesis of Bio-Based Symmetrical and Dissymmetrical Ethers.
Synthesis 2018;
50: 1849-1856
Further Information
Publication History
Publication Date:
18 June 2018 (online)
Significance
The authors have developed a continuous-flow system for the reductive alkylation of alcohols with aldehydes catalyzed by Pd/C in the presence of hydrogen, giving the corresponding ethers in 35–93% yield.
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Comment
In the long-term flow reaction of butan-1-ol with octanal, butyl octyl ether was obtained in 50% yield after eight hours.
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