Titanium-Catalyzed Stereoselective Formal [3+2] Cycloaddition
Diastereo- and Enantioselective Formal [3+2] Cycloaddition of Cyclopropyl Ketones and Alkenes via Ti-Catalyzed Radical Redox Relay.
J. Am. Chem. Soc. 2018;
17. April 2018 (online)
The discovery of new reactions mediated by organic radical intermediates continues to provide solutions to challenging synthetic problems in conventional two-electron chemistry. The authors have developed a Ti-catalyzed stereoselective formal [3+2] cycloaddition of cyclopropyl ketones and alkenes.
This catalytic cycloaddition through a radical-redox-relay mechanism provides chiral polysubstituted cyclopentane derivatives containing two contiguous stereogenic centers in high yields and with high diastereo- and enantioselectivities.