Abstract
Objective This study aims to investigate the perinatal outcome of fetuses with polyhydramnios
and/or accelerated growth among women with a normal oral glucose challenge test (oGCT).
Methods Singleton, nonanomalous pregnancies with an oGCT(< 130 mg/dL) at 24 to 28 weeks,
who subsequently demonstrate polyhydramnios (amniotic fluid index > 24 cm or maximum
vertical pocket > 8 cm) and/or accelerated growth (abdominal circumference > 95th
percentile) on two-third trimester examinations were studied. Maternal demographics,
delivery, and neonatal information were recorded. Cases were compared with a reference
group (normal oGCT with neither abnormal third-trimester growth nor polyhydramnios).
Results A total of 282 pregnancies were in the study group, and 663 were in the reference
group. Deliveries in the study group were at a higher risk for birth weight (BW)% > 90%,
standard deviation, and postpartum hemorrhage when compared with the reference group
(adjusted odds ratio: 2.3–5.6). Pregnancies complicated by both polyhydramnios and
accelerated fetal growth were significantly more likely to result in a BW% > 90% (odds
ratio [OR]: 18.5; 95% confidence interval [CI]: 8.9–38.6) and PPH (OR: 4.2; 95% CI:
2.4–7.6).
Conclusion Pregnancies with normal oGCT that develop polyhydramnios and accelerated growth are
at higher risk for maternal and neonatal complications. Isolated polyhydramnios without
accelerated growth increases the risk for delivery complications but not neonatal
morbidity.
Keywords
polyhydramnios - accelerated growth - normal glycemic screening - perinatal outcome
