Abstract
Objective We aimed to compare major complication rates in patients undergoing open versus endoscopic
resection of olfactory neuroblastoma (ONB) and to determine the prognostic utility
of the Kadish staging and Hyams grading systems with respect to progression-free survival
(PFS) and overall survival (OS).
Methods It is a retrospective review of experience in treating ONB at a single tertiary care
hospital from 1987 through 2015. Major complications were defined as cerebrospinal
fluid (CSF) leak, meningitis, osteomyelitis, tracheostomy, and severe neurologic injury.
Results Forty-one patients were included. An open approach was used in 34 (83%), endoscopic
in 6 (15%), and combined in 1 (2%) case. Rates of major complications by surgical
approach were 17% after endoscopic versus 31% after open (p = 0.65). There was no significant difference in PFS or OS based on Kadish B versus
C (PFS, p = 0.28; OS, p = 0.11) or Hyams grade 1 and 2 versus Hyams grade 3 and 4 (PFS, p = 0.53; OS, p = 0.38).
Conclusions There was no significant difference in major complications between open and endoscopic
approaches for the treatment of ONB. Patient stratification using the Kadish staging
and Hyams grading systems did not show significant differences in PFS or OS. Further
research is needed to determine if a different staging system would better predict
patient outcomes.
Keywords
olfactory neuroblastoma - endoscopic - complication - recurrence - survival - Kadish
- Hyams
