Abstract
Objective To compare growth and metabolic outcomes of premature infants receiving either Enfamil
liquid human milk fortifier (ELHMF) or Similac liquid human milk fortifier (SLHMF).
Study Design Infants born at ≤31 weeks' gestational age (GA) with birth weights <1,500 g and exclusively
fed on human milk (mother's milk and/or donor milk) were prospectively assigned alternatively
to one of the two liquid human milk fortifier (LHMF) groups. Baseline demographic,
growth, enteral nutrition, and laboratory data were compared after fortification.
Results In total, 31 preterm infants were recruited (ELHMF = 16; SLHMF = 15) with a mean
GA of 27.1 ± 2.1 weeks and birth weight of 993 ± 245 g. The SLHMF group had significantly
better weight gain as measured by individual weight z-scores (p = 0.008), better median weight gain velocity (p = 0.014), and less metabolic acidosis (p = 0.016). Overall weight gain was significantly better on mother's own milk in both
the fortifier groups. The SLHMF group showed a trend toward higher growth velocity
on donor milk compared with ELHMF (p = 0.06). We also observed a higher reticulocyte count (p = 0.003) in the SLHMF group compared with the ELHMF group.
Conclusion In premature infants, between the two liquid human milk fortifiers, ELHMF fortifier
is associated with relatively less weight gain and more metabolic acidosis.
Keywords
fortifier - weight gain - metabolic acidosis - prematurity
