Biology of T Helper Cells and Their Role in Neonatal Infection

Abstract

T lymphocytes play a central role in the adaptive immune system of the body to provide protection and surveillance against infections. Precursors of T cells begin their journey in the bone marrow and reach the thymus where they mature into naive T cells through a series of transitionary stages and interaction with thymic epithelial cells in various regions of the thymus to emerge as single-positive CD4+ or CD8+ T lymphocytes. The CD4+ naive T cells leave thymus and migrate to the peripheral lymphatic tissue for further differentiation into various subsets as a consequence of interaction with cytokines and altered gene regulation by specific transcription factors. This review summarized the intrathymic T-cell biology and various subsets of T cells, their characteristic cytokine production, and their role in neonatal infections.

Keywords

neonatal infection - T cells - T helper cells - Th1 - Th2

• References

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