Keywords
nasal valve - implant - rhinoplasty - lateral wall insufficiency
The nasal valve, first described in the early 20th century by Mink,[1] is a complex, three-dimensional, dynamically alternating structure that controls
nasal airflow resistance. A dysfunction of the nasal valve can lead to nasal obstruction
and a significant drop in the quality of life (QOL) for patients.[2] As defined by the Hagen–Poiseuille law, the flow through a tube is proportional
to the fourth power of the radius of the tube and inversely proportional to the pressure
difference across the tube. Thus, even a small decrease in the valve area can contribute
to severe nasal obstruction.
The nasal valve collapse (NVC) can be static or dynamic. Static NVC consists of an
anatomically narrowed nasal valve region, which causes obstruction. Dynamic NVC is
caused by insufficient cartilaginous support of the lateral nasal wall, leading to
lateral wall insufficiency.[3]
[4] Common causes of NVC are prior rhinoplasty, aging, nasal trauma, and congenital
abnormalities. Therapies to correct NVC include invasive surgical procedures and nonsurgical
solutions to temporarily dilate the nasal valve, such as Breathe Right strips or nasal
cones. Surgical strategies that involve septoplasty[5] or inferior turbinate reduction[6] may reduce negative inspiratory pressure by enlarging the airway, but these procedures
do not directly address weakness in the lateral wall. Procedures intended to address
the weakness of the lateral wall include cartilaginous grafts, typically harvested
from the nasal septum,[7] ear[8] or rib cartilage[9] that can be placed as lateral crural strut grafts,[10] alar batten grafts,[11] or butterfly grafts.[12] Implants made from nonabsorbable alloplastic materials have also been used for treatment
of NVC including expanded polytetrafluoroethylene[13] and high-density porous polyethylene.[14]
[15] These nonabsorbable materials have not gained wide use as they require invasive
surgical procedures and are associated with increased risks of infection, extrusion,
and the potential need for revision procedures.
While surgery to strengthen the lateral wall has been shown to significantly improve
the QOL for subjects suffering from nasal airway obstruction, current procedures can
be invasive and have the potential to permanently alter the patient's appearance.[16] In this study, a minimally invasive technique to address NVC by supporting the weakened
nasal lateral wall cartilage with an absorbable implant is described.
Methods
Study Design
This prospective, single cohort, nonrandomized study evaluating the safety and effectiveness
of an absorbable nasal implant (Spirox Inc., Menlo Park, CA) enrolled 30 subjects
at three investigational sites in Germany.
Consecutive subjects at each site were screened for potential enrollment. Eligible
subjects were invited to participate in the study. The baseline visit included a medical
history review, an evaluation of symptoms, an assessment of nasal airway obstruction,
and photodocumentation of nasal appearance. Demographic information, such as age,
gender, and date of onset of nasal obstruction, was collected. History of any prior
nasal trauma, surgery, and other medical conditions were noted. Physical examination
including anterior rhinoscopy and nasal endoscopy were performed to determine the
degree to which NVC contributed to the overall nasal airway obstruction. The degree
of nasal obstruction was rated by investigators on a severity scale as none, mild,
moderate, or severe.
Subjects were treated under general or local anesthesia. No concomitant nasal procedures
were performed. Follow-up visits took place at week 1 and months 1, 3, 6, and 12 postprocedure.
Internal and external nasal examinations were performed at each visit, as well as
Nasal Obstruction Symptom Evaluation (NOSE) score collection,[17] pain assessments, presence of a foreign body sensation, and assessment of cosmetic
changes. Physical examinations included an evaluation of nasal skin and nasal mucosa
appearance, and the presence of any implant extrusions, fractures, or migration. Cosmetic
changes were assessed using four photographic views obtained under both static and
full inhalation conditions (frontal view, left side, right side, and chin up). An
independent physician assessed cosmetic changes by comparing baseline images to the
follow-up images and categorizing the comparisons as no change, significantly better,
or significantly worse. For example, significantly better changes included structural
changes such as widening of the nasal vault, whereas significantly worse included
a narrowing of the nasal vault.
Subjects
Eligible subjects were adults with NVC identified as the primary contributor to nasal
obstruction with a NOSE score ≥ 55 at baseline. Subjects were ineligible if they had
septoplasty or turbinate reduction procedures within 6 months or rhinoplasty procedures
within 12 months prior to the planned index procedure. Additional exclusion criteria
were recurrent nasal infections, intranasal steroid treatment 2 weeks prior or planned
for 2 weeks postindex procedure, permanent nasal implants or dilators, a history of
(pre)cancerous or cancerous lesions, and/or radiation exposure or chemotherapy within
24 months of the study. Subjects with bleeding disorders, those with significant systemic
diseases, or those requiring nasal oxygen or continuous positive airway pressure (CPAP)
were not eligible to participate.
Implant and Delivery Tool
The absorbable nasal implant comprises a 70:30 blend of poly(L-lactide) and poly(D-lactide).
It is introduced through an endonasal insertion technique using a delivery tool. The
implant is primarily a ribbed cylindrical structure with an apical forked end. The
implant is designed to provide support to the upper and lower lateral nasal cartilages.
The geometry of the forked end is flexible and collapses to fit within the 16-gauge
cannula portion of the delivery tool prior to placement. The forked end first exits
the delivery tool cannula and expands open as the implant is deployed into the tissue.
This fork deployment is designed to anchor the implant in place during the acute implantation
step.
Once delivered, the apical, forked end of the implant is positioned over and adjacent
to the frontal process of the maxilla while the main body extends caudally toward
the alar region. The implant is flexible and therefore has the ability to conform
to the natural curvature of the lateral wall plane. In this location, the implant
is adjacent to the upper and lower lateral cartilages to provide support and strengthen
the lateral wall.
Implantation Technique
Implantation steps are illustrated in [Fig. 1]. Preprocedure, in each subject, the nasal anatomy as well as the area of maximum
lateral wall collapse during inspiration were examined and marked to identify the
target implant location and cannula insertion trajectory. The area of maximum collapse
was evaluated using the modified Cottle maneuver. The target implant location was
established to position the forked tip of the implant adjacent and across the maxilla
bone to provide cantilever support, and the main cylindrical body of the implant was
positioned along a trajectory to support the upper and lower lateral cartilages crossing
the area of maximum collapse. In cases where the collapse was too lateral for placement
of the implant, the implant was positioned as close as possible to the area of collapse
([Fig. 1A]). Although this positioning does not directly cross over the area of the collapse,
the implant should provide sufficient lateral wall support.
Fig. 1 Implantation technique. (A) Planned location of the implant relative to the area of collapse. (B) Placement of pierce point for delivery tool placement. (C) Delivery tool placement. (D) Delivery tool removal.
After subject marking, the implant was loaded into the delivery tool cannula and was
introduced through the vestibular skin using an intranasal entry point close to the
alar rim ([Fig. 1B]). Care was taken to ensure that the cannula at the entry point did not penetrate
through the lower lateral cartilage. The cannula was then advanced over the lateral
surface of the lower lateral cartilage and over the upper lateral cartilage to the
frontal process of the maxilla. From there, it was advanced over the maxilla to a
point where the apical portion of the implant would be positioned over the maxilla
while the main cylindrical portion is positioned in the lateral wall ([Fig. 1C]). The implant was then deployed, and the delivery tool was retracted and removed,
leaving the implant in place to support the upper and lower lateral cartilages ([Fig. 1D]).
Statistical Analysis
The NOSE scale is a validated disease-specific QOL instrument.[17] It uses a 20-point scale to capture breathing symptoms, with higher scores indicating
more severe symptoms than lower scores. NOSE score results are converted to a 100-point
scale by multiplying the total score by 5. This analysis includes the change in NOSE
scores from baseline (preoperative) to 3, 6, and 12 months. A paired t-test was used to determine whether the mean at follow-up time points was significantly
different from the preoperative mean while controlling for within-subject correlation.
A sensitivity analyses using a mixed model for repeated measures (MMRM) including
baseline score as a fixed covariate was performed for comparison.
A NOSE score severity classification system was developed by Lipan and Most based
on the data from 345 patients with and without nasal airway obstruction.[18] Their analysis derived clinically relevant severity classes of NOSE scores: mild
(5–25 points), moderate (30–50 points), severe (55–75 points), or extreme (80–100
points). The analysis reported herein used this classification system to report the
percentage of subjects in each category at baseline, 3, 6, and 12 months as well as
to classify subjects as responders or nonresponders to the procedure. Responders are
defined as subjects that have at least one NOSE class improvement or a NOSE score
reduction of at least 20%.
Statistical analyses were performed by an independent statistician (Axio Research,
Seattle, WA) using SAS version 9.4 and R version 3.2.3.
Results
Subject demographics and baseline disease characteristics are provided in [Table 1]. A significant percentage of the subjects had previous surgeries (66%); all subjects
had confirmed NVC as the primary contributor to nasal airway obstruction. A total
of 56 implants were placed in 30 subjects. Fourteen procedures took place in an operating
suite under general anesthesia, and 16 procedures were conducted in a clinic-based
setting with local anesthesia. Bilateral, single implants were placed in 26 subjects,
and a unilateral, single implant was placed in 4 subjects. Implants were successfully
delivered during the initial attempt in 91% of the cases. All procedures resulted
in successful placement of implant(s) to the target location(s). No device-related
adverse events were reported during the index procedure.
Table 1
Subject demographics and medical history
Attribute
|
|
Result
(N = 30)
|
Gender
|
Female
|
12 (40%)
|
Male
|
18 (60%)
|
Age (y)
|
Mean ± SD
|
51.1 ± 14.5
|
Minimum
|
24
|
Maximum
|
77
|
BMI (kg/m2)
|
Mean ± SD
|
27.6 ± 5.3
|
Minimum
|
22
|
Maximum
|
44
|
Race (n (%))
|
Asian
|
1 (3.3%)
|
White
|
28 (93.4%)
|
Black
|
1 (3.3%)
|
Baseline NOSE score
|
Mean ± SD
|
76.7 ± 14.8
|
Minimum
|
55
|
Maximum
|
100
|
Prior history
|
Nasal trauma
|
Yes
|
8 (26.7%)
|
No
|
22 (73.3%)
|
Nasal surgery
|
Yes
|
19 (63.3%)
|
No
|
11 (36.7%)
|
Years since most recent nasal surgery
|
<1 y[a]
|
3 (15.8%)
|
1–3 y
|
8 (42.1%)
|
3–5 y
|
1 (5.3%)
|
>5 y
|
7 (36.8%)
|
Nonsurgical nasal treatments
|
Yes
|
5 (16.7%)
|
No
|
25 (83.3%)
|
Medications
|
None
|
10 (33.3%)
|
Topical steroid use
|
1 (3.3%)
|
External nasal dilator
|
4 (13.3%)
|
Other medications
|
15 (50%)
|
Nasal endoscopy findings
|
None
|
15 (50%)
|
Deviated septum
|
13 (43.3%)
|
Inferior turbinate hypertrophy
|
2 (6.7%)
|
Middle meatus pathology
|
0 (0.0%)
|
Choanae and nasopharynx pathology
|
0 (0.0%)
|
Degree of nasal obstruction
|
Moderate
|
17 (56.7%)
|
Severe
|
13 (43.3%)
|
NVC primary contributor to nasal obstruction
|
Yes
|
30 (100%)
|
No
|
0 (0.0%)
|
Abbreviations: BMI, body mass index; NOSE, Nasal Obstruction Symptom Evaluation; NVC,
nasal valve collapse; SD, standard deviation.
a Does not include rhinoplasty or nasal valve surgery per protocol.
[Table 2] summarizes cumulative internal and external nasal examination results through 12
months of follow-up. There was no evidence of transcutaneous extrusions. The skin
examination was normal with two exceptions: one patient with a hematoma was noted
at the 1 week follow-up time point, and one patient with inflammation was noted at
the 1-month follow-up examination. Both observations resolved prior to the subsequent
follow-up examination. Internal nasal examinations were normal across all time points
with the two exceptions: one report of nondevice-related inflammation was noted at
1 week, and one nondevice-related infection was reported at 6-month follow-up (rhinitis).
There was no evidence of implant fracture and no findings of implant migration based
on internal and external physical examination.
Table 2
Nasal examination cumulative observations through 12 months follow-up
Attribute
|
(N = 30)
|
External nasal examination
|
Implant extrusion
|
|
No
|
30 (100%)
|
Skin appearance
|
|
Normal
|
28 (93.3%)
|
Hematoma
|
1 (3.3%)
|
Inflammation
|
1 (3.3%)
|
Internal nasal examination
|
Implant retrieval
|
|
Yes
|
3 (10%)
|
No
|
27 (90%)
|
Mucosal appearance
|
|
Normal
|
28 (93.3%)
|
Inflammation
|
1 (3.3%)[a]
|
Infection
|
1 (3.3%)[a]
|
Implant break/fracture
|
|
No
|
30 (100%)
|
Implant migration
|
|
No
|
30 (100%)
|
a Not device procedure related.
Three subjects required retrievals of a single implant within the 1-month follow-up
period. These events were attributed to the implantation technique in two instances
and possible nasal manipulation by the subject in one instance. The two retrievals
related to the implantation technique were attributed to an incomplete delivery, resulting
in the tip of the caudal end of the implant lying very close to the cannula entry
point causing subsequent exposure. Using forceps, the investigator was able to remove
the entire implant without difficulty and without the need for anesthesia. The third
retrieval occurred when a tip of the implant protruding through the implantation site
on one side was observed and retrieved by the investigator. In this case, the subject
reported to have blown his nose forcibly, multiple times during the week following
the procedure. There was no erythema, bleeding, swelling, or pain. The protruding
portion of the implant appeared to be mobile and was removed easily with forceps and
without anesthetic. During the nasal endoscopic examination, it was noted that there
was no sign of infection or a lesion due to the remaining upper part of the implant
on the lateral nasal wall. These three device-related events resolved with no clinical
sequelae.
Follow-up outcomes including pain assessments, evaluation of foreign body sensation,
the independent assessment of cosmetic change, and adverse events at 1, 3, 6, and
12 months are summarized in [Table 3]. There were no reports of moderate or severe pain at 1, 3, 6, or 12 months. Four
subjects reported a “mild” foreign body sensation at month 1, and three subjects at
month 12. Independent physician photography review reported one subject with an adverse
cosmetic change at 3 months postprocedure that subsequently resolved. At 6 and 12
months, there were no adverse cosmetic changes identified, and three subjects were
classified as having significant cosmetic improvements at 12 months, where the independent
reviewer observed less alar retraction for 2 subjects, and 1 subject where the nasal
vaults were more open bilaterally. Approximately half of the subjects wore eyeglasses
throughout the follow-up period. There were five adverse event related to the study
device/procedure that occurred within the 1-month postprocedure follow-up. No subsequent
device/procedure related adverse event was observed.
Table 3
Device tolerability, cosmetic changes, and adverse events at 1, 3, 6, and 12 months
Attribute
|
1 mo postprocedure
|
3 mo postprocedure
|
6 mo postprocedure
|
12 mo postprocedure
|
(N = 30)
|
(N = 29)
|
(N = 30)
|
(N = 29)
|
Pain assessment
|
None/mild
|
30 (100%)
|
29 (100%)
|
29 (96.7%)
|
29 (100%)
|
Moderate/severe
|
0 (0.0%)
|
0 (0.0%)
|
0 (0.0%)
|
0 (0.0%)
|
Not assessed
|
0 (0.0%)
|
0 (0.0%)
|
1 (3.3%)
|
0 (0.0%)
|
Foreign body sensation
|
None
|
26 (86.7%)
|
27 (93.1%)
|
27 (90.0%)
|
26 (89.7%)
|
Mild
|
4 (13.3%)
|
2 (6.9%)
|
3 (10%)
|
3 (10.3%)
|
Photography review (cosmetic change from baseline)
|
(
N
= 30)
|
(
N
= 29)
|
(
N
= 27)
|
(
N
= 27)
|
None
|
28 (93.3%)
|
25 (86.2%)
|
24 (88.9%)
|
24 (88.9%)
|
Yes–insignificant
|
0 (0.0%)
|
0 (0.0%)
|
0 (0.0%)
|
0 (0.0%)
|
Yes–significant–worse
|
0 (0.0%)
|
1 (3.4%)
|
0 (0.0%)
|
0 (0.0%)
|
Yes–significant–better
|
2 (6.7%)
|
3 (10.3%)
|
3 (11.1%)
|
3 (11.1%)
|
Adverse events
|
Device related[a]
|
5
|
|
|
|
Otherb
|
4
|
4
|
2
|
−
|
a Device-related adverse events include three device retrievals, one hematoma, and
one inflammation. bOther nondevice-/procedure-related adverse events includes rhinitis, common colds,
vertigo, rhinorrhea, acute hypertension, headache, hernia repair, and epistaxis.
Within-subject changes in NOSE score from baseline to 3, 6, and 12 months are summarized
in [Table 4]
. The mean preoperative NOSE score was 76.7 ± 14.8. Twelve months postprocedure, the
mean NOSE score was 35.2 ± 29.2, reflecting an average within-subject reduction of
–40.9 ± 31.2 points. The paired t-test showed significant differences between the mean baseline and follow-up NOSE
score at all three follow-up time-points (p < 0.001 for months 3, 6, and 12). MMRM results were similar. [Table 5] presents the response rates at 3, 6, and 12 months. The majority (76%) of subjects
were classified as responders at 12 months, demonstrating sustained reductions in
nasal obstruction symptoms. [Fig. 2] presents NOSE score categories preprocedure and at 12 months in terms of the number
of subjects in each NOSE severity class. Preprocedure, all subjects were classified
as extreme or severe. At 12 months, 66% of the subjects were classified as mild or
moderate, and the number of subjects classified as extreme and severe was reduced
to 3 and 31%, respectively.
Fig. 2 Nasal Obstruction Symptom Evaluation (NOSE) severity class at baseline and 12 months
postprocedure. *One subject who was classified as extreme at baseline did not complete
the 12-month NOSE score assessment. **Four subjects at 12-month follow-up had a NOSE
score of 0 that have been categorized as mild for this analysis.
Table 4
Pre- and postprocedure NOSE scores and change from baseline value
Statistics
|
Baseline
|
3 mo postprocedure
|
6 mo postprocedure
|
12 mo postprocedure
|
NOSE score
|
NOSE score
|
Change from baseline
|
NOSE score
|
Change from baseline
|
NOSE score
|
Change from baseline
|
N
|
30
|
29
|
29
|
30
|
30
|
29
|
29
|
Mean
|
76.7
|
28.4
|
-48.4
|
33.3
|
-43.3
|
35.2
|
-40.9
|
SD
|
14.8
|
26.9
|
27.8
|
29.7
|
31.3
|
29.2
|
31.2
|
Median
|
75
|
20
|
-50
|
27.5
|
-45
|
35
|
-45
|
p-Value[a]
|
|
|
<0.001
|
|
<0.001
|
|
<0.001
|
Abbreviations: NOSE, Nasal Obstruction Symptom Evaluation; SD, standard deviation.
a
p-Values are from paired t-tests comparing the mean preoperative NOSE score to the mean score at each follow-up
time point.
Table 5
Response rate[a] at 3, 6, and 12 months after procedure
|
N
|
Responders,b N (%)
|
3 mo postprocedure
|
29
|
25 (86.2%)
|
6 mo postprocedure
|
30
|
24 (80%)
|
12 mo postprocedure
|
29
|
22 (75.9%)
|
a Response rate is based on the number of subjects with data at each visit. bResponders are subjects with an improvement of at least one NOSE score category or
a 20% reduction in NOSE score.
Discussion
Nasal airway obstruction can be caused by a combination of anatomical and structural
abnormalities, including a weakened lateral nasal wall that can result in NVC.
Data presented herein describe the first-in-human experience characterizing the use
of a novel absorbable implant to support the upper and lower lateral cartilages in
subjects with NVC through 12 months. Subjects noted a significant reduction in nasal
obstruction symptoms after the procedure through 12 months. The strengths of this
study are of a disease-specific instrument for treatment of nasal obstruction due
to NVC, long-term follow-up, and prospective patient evaluation.
Recently, a meta-analysis was conducted by Rhee et al[19] of studies covering conventional invasive surgical procedures such as septoplasty,
turbinate reduction, and functional rhinoplasty, in combination or alone for treatment
of nasal airway obstruction. The analysis showed a weighted mean pretreatment NOSE
score of 65 points and a weighted mean posttreatment NOSE score of 23 points, resulting
in an improvement from baseline of 42 points. In this study, subjects with NVC as
a primary contributor to their nasal airway obstruction symptoms were treated in stand-alone
procedures. The results from this study are within the range of the meta-analysis
findings with a mean improvement in NOSE score of 41 points at 12 months. In addition,
this study showed 76% of the subjects were classified as responders defined as having
at least one NOSE class improvement or a NOSE score reduction of at least 20%.
The implant created no adverse cosmetic change as confirmed by the independent photographic
review. Spreader grafts and batten grafts may lead to changes in the external appearance
of the nose, including widening of the middle third of the nose, blunting of the alar
crease, and widening of the nasal tip.[16] However, many of these grafting procedures are more extensive (i.e., require cartilage
repair or replacement) than the procedures indicated for the subject implant (i.e.,
cartilage support only). The lack of significant cosmetic changes in this study may
be attributable to the design and position of the implant; the low profile of the
implant, particularly in the region that aligns with the thinner skin above the maxillary
transition, allows for minimal change in the external nasal appearance. The presence
of the implant in the nasal wall was well-tolerated by the subjects as evidenced by
minimal pain scores and minimal foreign body sensation to the device's presence in
the nose. The implant also did not interfere with the use of eye glasses.
There were a total of five device-related adverse events reported in four subjects.
These events included one case of hematoma, one case of inflammation, and three of
implant retrievals. All events resolved with no clinical sequelae. Investigators concluded
that the three implant retrievals were the result of suboptimal implantation method
during initial cases or possibly significant patient nasal manipulation during the
first postoperative week. There was no evidence of adverse physiological tissue rejection,
infection, and/or significant implant migrations in contrast with the extrusion events
reported in the literature for more invasive procedures involving permanent, nonabsorbable
allografts.[13]
[14]
The efficacy of the implant in reducing nasal obstruction is demonstrated by a significant
reduction in NOSE scores through 12 months of follow-up, the gold standard for rhinoplasty
studies. This current study represents a first-in-man demonstration of a new technique,
as it has a modest sample size, a nonrandomized study design, and a heterogeneous
subject population with respect to prior history of surgery. Future studies with a
lager patient population should address this as well as to include comparisons of
the efficacy, morbidity, and cost-effectiveness of this technique to standard surgical
techniques and placebo treatments.
The absorbable nasal implant used in this study comprised 70% poly(L-lactide) and
30% poly(D-lactide). This nontoxic, biocompatible copolymer has an extensive history
of use in a variety of medical applications such as suture materials, orthopedic,
dental, ophthalmic, and craniofacial implants. Once implanted in vivo, over time,
the copolymer chains degrade into water soluble fragments that are naturally found
in the body (i.e., lactic acid) and are metabolized and eliminated through normal
physiologic pathways. Landes et al studied 70% poly(L-lactide) 30% poly(D-lactide)
copolymer degradation in human subjects in the maxillofacial region applications.[20] The copolymers decomposed reliably in patients within 24 months on average, leaving
only extremely small granules that powder upon finger touch. Landes et al also noted
fibrous capsule formation at around 3 months postimplantation. For the current application
for the support of the nasal lateral wall, it is hypothesized that the eventual encapsulation
of the implant and then replacement of the implant substrate with fibrocollagenous
scar tissue may provide support to the lateral wall over time; however, the strength
and quality of the scar, as well as the potential for a prolonged improvement that
outlasts the mechanical integrity of the absorbable implant is yet to be determined.
In summary, NVC attributed to a weak lateral cartilage is a common cause of nasal
obstruction. However, due to complex surgical techniques for correcting NVC and associated
cosmetic consequences, NVC frequently remains untreated.[2] Hence, in this study, we present a first-in-human experience with a minimally invasive
technique for supporting the lateral nasal wall with low cosmetic risk and using a
widely used absorbable material with well-known safety profile.