Infectious Complications of Peritoneal Dialysis in Children with End-Stage Renal Disease

Abstract

End-stage renal disease (ESRD) affects children of all ages worldwide. During their lifetimes, these children undergo a continuous sequence of renal replacement therapies: hemodialysis (HD), peritoneal dialysis (PD), and transplantation, and consequently, face a significantly shortened life expectancy. Although transplant remains the treatment of choice, 75% of children with ESRD now require treatment with dialysis prior to receiving a kidney transplant, and ultimately, upon allograft failure, will need to return to dialysis. Dialysis is, for that reason, a life-saving therapy for children and adolescents with ESRD, and conditions that complicate or negatively impact dialysis need to be prevented or minimized in this population. With patients on PD, peritonitis is an important cause of morbidity, mortality, and functional failure of the peritoneal membrane and a complication that has been reported to occur more commonly in children than in adults.

Keywords

peritoneal dialysis - infections - children

• References

• 1 Saran R, Li Y, Robinson B. , et al. US Renal Data System 2014 Annual Data Report: epidemiology of kidney disease in the United States. Am J Kidney Dis 2015; 66 (01) (Suppl. 01) S1-S305
• 2 Furth SL, Donaldson LA, Sullivan EK, Watkins SL. ; North American Pediatric Renal Transplant Cooperative Study. Peritoneal dialysis catheter infections and peritonitis in children: a report of the North American Pediatric Renal Transplant Cooperative Study. Pediatr Nephrol 2000; 15 3-4 179-182
• 3 Warady BA, Feneberg R, Verrina E. , et al; IPPR. Peritonitis in children who receive long-term peritoneal dialysis: a prospective evaluation of therapeutic guidelines. J Am Soc Nephrol 2007; 18 (07) 2172-2179
• 4 Alexander SR, Warady BA. The demographics of dialysis in children. In: Warady BA, Schaefer FS, Fine RN, Alexander SR. , eds. Pediatric Dialysis. Kluwer, Dordrecht; 2004: 35-46
• 5 Schaefer F, Feneberg R, Aksu N. , et al. Worldwide variation of dialysis-associated peritonitis in children. Kidney Int 2007; 72 (11) 1374-1379
• 6 Chadha V, Schaefer FS, Warady BA. Dialysis-associated peritonitis in children. Pediatr Nephrol 2010; 25 (03) 425-440
• 7 The North American Pediatric Renal Trials and Collaborative Studies. NAPRTCS 2011 annual dialysis report (2011). Available at: https://web.emmes.com/study/ped/annlrept/annualrept2011.pdf . Accessed October 7, 2016
• 8 Warady BA, Bakkaloglu S, Newland J. , et al. Consensus guidelines for the prevention and treatment of catheter-related infections and peritonitis in pediatric patients receiving peritoneal dialysis: 2012 update. Perit Dial Int 2012; 32 (02) (Suppl. 02) S32-S86
• 9 Stewart CL, Acker SN, Pyle LL. , et al. Factors associated with peritoneal dialysis catheter complications in children. J Pediatr Surg 2016; 51 (01) 159-162
• 10 Ravelli AM. Gastrointestinal function in chronic renal failure. Pediatr Nephrol 1995; 9 (06) 756-762
• 11 Cleper R, Davidovits M, Kovalski Y, Samsonov D, Amir J, Krause I. Peritonitis in a pediatric dialysis unit: local profile and implications. Isr Med Assoc J 2010; 12 (06) 348-352
• 12 Sethna CB, Bryant K, Munshi R. , et al; SCOPE Investigators. Risk factors for and outcomes of catheter-associated peritonitis in children: the SCOPE Collaborative. Clin J Am Soc Nephrol 2016; 11 (09) 1590-1596
• 13 Chand DH, Brier ME, Strife CF. ; Medical Review Board of The Renal Network, Inc. Multicenter study of effects of pediatric peritoneal dialysis practices on bacterial peritonitis. Pediatr Nephrol 2010; 25 (01) 149-153
• 14 Miles R, Hawley CM, McDonald SP. , et al. Predictors and outcomes of fungal peritonitis in peritoneal dialysis patients. Kidney Int 2009; 76 (06) 622-628
• 15 Sardegna KM, Beck AM, Strife CF. Evaluation of perioperative antibiotics at the time of dialysis catheter placement. Pediatr Nephrol 1998; 12 (02) 149-152
• 16 Auron A, Simon S, Andrews W. , et al. Prevention of peritonitis in children receiving peritoneal dialysis. Pediatr Nephrol 2007; 22 (04) 578-585
• 17 Tsai YC, Tsai TC, Tsaf JD, Huang FY, Lin CC, Sheu JC. Clinical analysis of chronic peritoneal dialysis related peritonitis in children. Acta Paediatr Taiwan 2006; 47 (02) 72-76
• 18 Vas S, Oreopoulos DG. Infections in patients undergoing peritoneal dialysis. Infect Dis Clin North Am 2001; 15 (03) 743-774
• 19 Hoshii S, Wada N, Honda M. ; Japanese Study Group of Pediatric Peritoneal Dialysis. A survey of peritonitis and exit-site and/or tunnel infections in Japanese children on PD. Pediatr Nephrol 2006; 21 (06) 828-834
• 20 Araki Y, Hataya H, Ikeda M, Ishikura K, Honda M. Intranasal mupirocin does not prevent exit-site infections in children receiving peritoneal dialysis. Perit Dial Int 2003; 23 (03) 267-269
• 21 Raaijmakers R, Schröder C, Monnens L, Cornelissen E, Warris A. Fungal peritonitis in children on peritoneal dialysis. Pediatr Nephrol 2007; 22 (02) 288-293
• 22 Bordador EB, Johnson DW, Henning P. , et al; Australian and New Zealand Dialysis and Transplant Registry. Epidemiology and outcomes of peritonitis in children on peritoneal dialysis in Australasia. Pediatr Nephrol 2010; 25 (09) 1739-1745
• 23 Michel C, Courdavault L, al Khayat R, Viron B, Roux P, Mignon F. Fungal peritonitis in patients on peritoneal dialysis. Am J Nephrol 1994; 14 (02) 113-120
• 24 Goldie SJ, Kiernan-Tridle L, Torres C. , et al. Fungal peritonitis in a large chronic peritoneal dialysis population: a report of 55 episodes. Am J Kidney Dis 1996; 28 (01) 86-91
• 25 Bren A. Fungal peritonitis in patients on continuous ambulatory peritoneal dialysis. Eur J Clin Microbiol Infect Dis 1998; 17 (12) 839-843
• 26 Warady BA, Bashir M, Donaldson LA. Fungal peritonitis in children receiving peritoneal dialysis: a report of the NAPRTCS. Kidney Int 2000; 58 (01) 384-389
• 27 Lane JC, Warady BA, Feneberg R. , et al; International Pediatric Peritonitis Registry. Relapsing peritonitis in children who undergo chronic peritoneal dialysis: a prospective study of the international pediatric peritonitis registry. Clin J Am Soc Nephrol 2010; 5 (06) 1041-1046
• 28 Warady BA, Schaefer F, Holloway M. , et al; International Society for Peritoneal Dialysis (ISPD) Advisory Committee on Peritonitis Management in Pediatric Patients. Consensus guidelines for the treatment of peritonitis in pediatric patients receiving peritoneal dialysis. Perit Dial Int 2000; 20 (06) 610-624
• 29 Flanigan MJ, Freeman RM, Lim VS. Cellular response to peritonitis among peritoneal dialysis patients. Am J Kidney Dis 1985; 6 (06) 420-424
• 30 Gould IM, Casewell MW. The laboratory diagnosis of peritonitis during continuous ambulatory peritoneal dialysis. J Hosp Infect 1986; 7 (02) 155-160
• 31 Koopmans JG, Boeschoten EW, Pannekeet MM. , et al. Impaired initial cell reaction in CAPD-related peritonitis. Perit Dial Int 1996; 16 (01) (Suppl. 01) S362-S367
• 32 Rocklin MA, Teitelbaum I. Noninfectious causes of cloudy peritoneal dialysate. Semin Dial 2001; 14 (01) 37-40
• 33 Shemin D, Bostom AG, Lambert C, Hill C, Kitsen J, Kliger AS. Residual renal function in a large cohort of peritoneal dialysis patients: change over time, impact on mortality and nutrition. Perit Dial Int 2000; 20 (04) 439-444
• 34 North American Pediatric Renal Trials and Cooperative Studies (NAPRTCS). 2007 Annual report. Available at: https://web.emmes.com/study/ped/annlrept/annlrept.html . Accessed October 9, 2016
• 35 Vidal E, Edefonti A, Murer L. , et al; Italian Registry of Paediatric Chronic Dialysis. Peritoneal dialysis in infants: the experience of the Italian Registry of Paediatric Chronic Dialysis. Nephrol Dial Transplant 2012; 27 (01) 388-395
• 36 Somers MSA, Neu A, Richardson T, Rodean J, Lawlor J, Swartz S. Exit site infections in children on chronic peritoneal dialysis: findings from the standardizing care to improve outcomes in pediatric end stage renal disease collaborative (SCOPE). Pediatr Nephrol 2016; 29 (09) 1477-1484
• 37 Piraino B. Peritonitis as a complication of peritoneal dialysis. J Am Soc Nephrol 1998; 9 (10) 1956-1964
• 38 Nailescu C, Xu X, Zhou H. , et al. Influenza vaccine after pediatric kidney transplant: a Midwest Pediatric Nephrology Consortium study. Pediatr Nephrol 2011; 26 (03) 459-467