Generation of glucosamine from plant material

The use of glucosamine as anti-osteoarthritis agent has been intensively developed during the last decade, as well as uses in cosmetic products. The global glucosamine market corresponds to ˜6,000 metric tons, China being the main producer. The industrial glucosamine is mainly a pure compound obtained from the hydrolysis of shellfish. There is a market for alternative sources; e.g. in 2007, Cargill has developed its Regenasure® ingredient [1], the only non-animal glucosamine available on the market, which was determined as generally recognized as safe (GRAS). In contrast to other glucosamine products, which are derived from the shell of crabs, lobster and shrimps, this fungus-derived ingredient eliminates fears over shellfish allergies. In order to provide a plant derived glucosamine, we developed a proprietary drying process to form glucosamine in plant raw material through specific gentle drying conditions [2 – 5]. Chicory, containing a high level of inulin (fructose polysaccharide), is the main plant raw material used. The glucosamine content, quantified by an anion exchange chromatography (HPAE-PAD), can reach up to 10% of the dry material of this vegetable. Our proprietary process currently represents the only way to produce glucosamine from plants for food, pet food, nutraceutical or cosmetic applications.

Fig. 1: Chicory roots and glucosamine

Keywords: Chicory roots, glucosamine, drying process, anti-osteoarthritis, HPAE-PAD.

References:

[1] Lawrence EF, John AB, James RT, Brenda LR. Glucosamine and method of making glucosamine from microbial biomass. US7816514 B2, 19 October 2010

[2] Husson J, Courtois D. Generation of glucosamine from plant material. WO2015067640 A1 (Nestec SA (CH)), 14 May 2015

[3] Petiard V, Michaux S, Courtois D. Production of Glucosamine from Plant Species. WO2006/120007 (Nestec SA (CH)), 16 November 2006

[4] Courtois D. Michaux S., Goulois E. Production of glucosamine from plant species. WO2006/120009 (Nestec SA (CH)), 16 November 2006

[5] Courtois D. Michaux S, Petiard V, Touche A. Production of Glucosamine from Plant Species. WO2005/053710 (Nestec SA (CH)), 16 June 2005

 

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