Asymmetric Copper Hydride Catalyzed Coupling Reaction to Access Chiral Ketones
Enantioselective CuH-Catalyzed Hydroacylation Employing Unsaturated Carboxylic Acids as Aldehyde Surrogates.
J. Am. Chem. Soc. 2017;
18 August 2017 (online)
The preparation of chiral α-aryl dialkyl ketones is an important challenge for the synthesis community. The authors have developed a Cu-catalyzed enantioselective hydroacylation of α,β-unsaturated carboxylic acids with aryl alkenes.
This direct asymmetric copper hydride catalysis is highly effective in coupling α,β-unsaturated carboxylic acids to aryl alkenes to afford the corresponding chiral α-aryl dialkyl ketones in moderate yields and with high enantioselectivities.