Synfacts 2017; 13(09): 0937
DOI: 10.1055/s-0036-1590772
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Asymmetric Copper Hydride Catalyzed Coupling Reaction to Access Chiral Ketones

Hisashi Yamamoto
Wataru Muramatsu
Zhou Y. Bandar JS. Buchwald SL. * Massachusetts Institute of Technology, Cambridge, USA
Enantioselective CuH-Catalyzed Hydroacylation Employing Unsaturated Carboxylic Acids as Aldehyde Surrogates.

J. Am. Chem. Soc. 2017;
139: 8126-8129
Further Information

Publication History

Publication Date:
18 August 2017 (online)



The preparation of chiral α-aryl dialkyl ketones is an important challenge for the synthesis community. The authors have developed a Cu-catalyzed enantioselective hydroacylation of α,β-unsaturated carboxylic acids with aryl alkenes.



This direct asymmetric copper hydride catalysis is highly effective in coupling α,β-unsaturated carboxylic acids to aryl alkenes to afford the corresponding chiral α-aryl dialkyl ketones in moderate yields and with high enantioselectivities.