Enantioselective Palladium(II)-Catalyzed Borylation
Pd(II)-Catalyzed Enantioselective C(sp3)–H Borylation.
J. Am. Chem. Soc. 2017;
16. Mai 2017 (online)
The authors developed a palladium(II)-catalyzed borylation of cyclic amides by using chiral bidentate ligands. A wide variety of borylated cyclobutanes bearing an amide group were obtained with high selectivities.
A transformation of the product, including the removal of the amide auxiliary, was accomplished to demonstrate the synthetic utility of the reaction. An asymmetric induction model is also proposed.