Yang J.
Rérat A.
Lim YJ.
Gosmini C.
Yoshikai N.
* Nanyang Technological University, Singapore, and Université Paris Saclay, France
Cobalt-Catalyzed Enantio- and Diastereoselective Intramolecular Hydroacylation of
Trisubstituted Alkenes.
Angew. Chem. Int. Ed. 2017;
56: 2449-2453
Key words
cobalt catalysis - hydroacylation - trisubstituted alkenes - indanones
Significance
A cobalt-catalyzed hydroacylation reaction is described. By using a simple chiral
bis-phosphine ligand, the authors were able to furnish various enantioenriched indanones
in moderate to excellent yields, enantioselectivity, and diastereoselectivity.
Comment
Hydroacylation reactions are typically carried out with expensive rhodium catalysts.
The application of less expensive cobalt catalyst enabled the authors to hydroacylate
trisubstituted olefins under mild conditions. The mechanism is presumed to be analogous
to that of the rhodium-catalyzed hydroacylation reaction.
