Photoredox C(sp2)–C(sp3) Cross-Couplings in Flow

Paul Knochel; Marthe Ketels

doi:10.1055/s-0036-1589685

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Synfacts 2016; 12(12): 1285
DOI: 10.1055/s-0036-1589685

Metal-Mediated Synthesis

Photoredox C(sp²)–C(sp³) Cross-Couplings in Flow

Rezensent(en):

Paul Knochel

,

Marthe Ketels

Lima F, Kabeshov MA, Tran DN, Battilocchio C, Sedelmeier J, Sedelmeier G, Schenkel B, Ley SV * University of Cambridge, UK and Novartis Pharma AG, Switzerland
Visible Light Activation of Boronic Esters Enables Efficient Photoredox C(sp²)–C(sp³) Cross-Couplings in Flow.

Angew. Chem. Int. Ed. 2016;
55: 14085-14089

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Publikationsverlauf

Publikationsdatum:
17. November 2016 (online)

Abstract
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Key words

photoredox cross-coupling - boronic esters - flow chemistry

Significance

The authors report an efficient and high-throughput continuous flow process employing a new method for the photoredox activation of boronic esters.

Comment

No additive other than the photoredox catalyst is required for the coupling of the heteroaromatic nitriles and pinacol boronic esters because the nitrogen-containing heterocycle serves as the activator for the boronic ester.

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