Huo X, He R, Zhang X, Zhang W * Shanghai Jiao Tong University, P. R. of China
An Ir/Zn Dual Catalysis for Enantio- and Diastereodivergent α-Allylation of α-Hydroxyketones.
J. Am. Chem. Soc. 2016;
138: 11093-11096
Key words
α-hydroxyketones - dual metal catalysis - asymmetric allylation
Significance
A dual metal-catalyzed asymmetric allylation of α-hydroxyketones is described. Chiral
iridium and zinc complexes are employed for this transformation to furnish stereodefined
α-hydroxyketones.
Comment
Multi-metal asymmetric catalysis is a newly emerging field in catalysis. Exploitation
of the preferential binding affinity of chiral ligands to specific metal centers allows
chemo- and stereoselective formation of the desired products.
