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Synfacts 2016; 12(11): 1153
DOI: 10.1055/s-0036-1589371
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Enantio- and Diastereoselective α-Allylation

Contributor(s):
Mark Lautens
,
Alvin Jang
Huo X, He R, Zhang X, Zhang W * Shanghai Jiao Tong University, P. R. of China
An Ir/Zn Dual Catalysis for Enantio- and Diastereodivergent α-Allylation of α-Hydroxyketones.

J. Am. Chem. Soc. 2016;
138: 11093-11096
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Further Information

Publication History

Publication Date:
18 October 2016 (online)

 
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Key words

α-hydroxyketones - dual metal catalysis - asymmetric allylation

Significance

A dual metal-catalyzed asymmetric allylation of α-hydroxyketones is described. Chiral iridium and zinc complexes are employed for this transformation to furnish stereodefined α-hydroxyketones.


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Comment

Multi-metal asymmetric catalysis is a newly emerging field in catalysis. Exploitation of the preferential binding affinity of chiral ligands to specific metal centers allows chemo- and stereoselective formation of the desired products.


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