IgG4-Related Disease in Organs Other than the Hepatobiliary-Pancreatic System

Abstract

Immunoglobulin G4-related disease (IgG4-RD) is a new disease entity that was established in this century. It is a systemic and chronic inflammatory disorder. Autoimmune pancreatitis is a representative condition, but there is clearly involvement from other organs, including the kidneys, the retroperitoneal cavity, the lungs, and the thyroid, lacrimal, salivary, pituitary, and prostate glands. To aid in the resolution of the numerous issues related to IgG4-RD, the authors established a registry system of patients in multicenter institutes with IgG4-RD—the SMART registry. Using SMART registry data, they provide an overview of the involvement of organs other than the hepatobiliary-pancreatic system in IgG4-RD and emphasize the importance of consultation and cooperation with other specialists in the diagnosis, treatment, and management of patients with IgG4-RD.

Keywords

dacryoadenitis - sialadenitis - interstitial nephritis - retroperitoneal fibrosis - diagnostic criteria

• References

• 1 Umehara H, Okazaki K, Masaki Y , et al; Research Program for Intractable Disease by Ministry of Health, Labor and Welfare (MHLW) Japan G4 team. A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details. Mod Rheumatol 2012; 22 (1) 1-14
• 2 Yamamoto M, Takahashi H, Shinomura Y. Mechanisms and assessment of IgG4-related disease: lessons for the rheumatologist. Nat Rev Rheumatol 2014; 10 (3) 148-159
• 3 Deshpande V, Zen Y, Chan JK , et al. Consensus statement on the pathology of IgG4-related disease. Mod Pathol 2012; 25 (9) 1181-1192
• 4 Brito-Zerón P, Ramos-Casals M, Bosch X, Stone JH. The clinical spectrum of IgG4-related disease. Autoimmun Rev 2014; 13 (12) 1203-1210
• 5 Uchida K, Masamune A, Shimosegawa T, Okazaki K. Prevalence of IgG4- related disease in Japan based on nationwide survey in 2009. Int J Rheumatol 2012; 2012: 358371
• 6 Kanno A, Nishimori I, Masamune A , et al; Research Committee on Intractable Diseases of Pancreas. Nationwide epidemiological survey of autoimmune pancreatitis in Japan. Pancreas 2012; 41 (6) 835-839
• 7 Kanno A, Masamune A, Okazaki K , et al; Research Committee of Intractable Diseases of the Pancreas. Nationwide epidemiological survey of autoimmune pancreatitis in Japan in 2011. Pancreas 2015; 44 (4) 535-539
• 8 Yamamoto M, Yajima H, Takahashi H , et al. Everyday clinical practice in IgG4-related dacryoadenitis and/or sialadenitis: results from the SMART database. Mod Rheumatol 2015; 25 (2) 199-204
• 9 Yamamoto M, Harada S, Ohara M , et al. Clinical and pathological differences between Mikulicz's disease and Sjögren's syndrome. Rheumatology (Oxford) 2005; 44 (2) 227-234
• 10 Kitagawa S, Zen Y, Harada K , et al. Abundant IgG4-positive plasma cell infiltration characterizes chronic sclerosing sialadenitis (Küttner's tumor). Am J Surg Pathol 2005; 29 (6) 783-791
• 11 Yamamoto M, Takahashi H, Shinomura Y. Mikulicz's disease and the extraglandular lesions. Curr Immunol Rev 2011; 7 (2) 162-171
• 12 Yamamoto M, Takahashi H, Ohara M , et al. A new conceptualization for Mikulicz's disease as an IgG4-related plasmacytic disease. Mod Rheumatol 2006; 16 (6) 335-340
• 13 Shimizu Y, Yamamoto M, Naishiro Y , et al. Necessity of early intervention for IgG4-related disease—delayed treatment induces fibrosis progression. Rheumatology (Oxford) 2013; 52 (4) 679-683
• 14 Takahira M, Ozawa Y, Kawano M , et al. Clinical aspects of IgG4-related orbital inflammation in a case series of ocular adnexal lymphoproliferative disorders. Int J Rheumatol 2012; 2012: 635473
• 15 Kawakami Y, Yamamoto M, Tabeya T , et al. IgG4-related orbital tumour with eye enucleation—infra-orbital nerve enlargement. Rheumatology (Oxford) 2014; 53 (4) 610
• 16 Ohshima K, Sogabe Y, Sato Y. The usefulness of infraorbital nerve enlargement on MRI imaging in clinical diagnosis of IgG4-related orbital disease. Jpn J Ophthalmol 2012; 56 (4) 380-382
• 17 Sogabe Y, Miyatani K, Goto R, Ishii G, Ohshima K, Sato Y. Pathological findings of infraorbital nerve enlargement in IgG4-related ophthalmic disease. Jpn J Ophthalmol 2012; 56 (5) 511-514
• 18 Goto H, Takahira M, Azumi A ; Japanese Study Group for IgG4-Related Ophthalmic Disease. Diagnostic criteria for IgG4-related ophthalmic disease. Jpn J Ophthalmol 2015; 59 (1) 1-7
• 19 Saeki T, Nishi S, Imai N , et al. Clinicopathological characteristics of patients with IgG4-related tubulointerstitial nephritis. Kidney Int 2010; 78 (10) 1016-1023
• 20 Saeki T, Imai N, Ito T, Yamazaki H, Nishi S. Membranous nephropathy associated with IgG4-related systemic disease and without autoimmune pancreatitis. Clin Nephrol 2009; 71 (2) 173-178
• 21 Kawano M, Saeki T, Nakashima H , et al. Proposal for diagnostic criteria for IgG4-related kidney disease. Clin Exp Nephrol 2011; 15 (5) 615-626
• 22 Takahashi N, Kawashima A, Fletcher JG, Chari ST. Renal involvement in patients with autoimmune pancreatitis: CT and MR imaging findings. Radiology 2007; 242 (3) 791-801
• 23 Ozaki K, Miyayama S, Ushiogi Y, Matsui O. Renal involvement of polyarteritis nodosa: CT and MR findings. Abdom Imaging 2009; 34 (2) 265-270
• 24 Dufour JF, Le Gallou T, Cordier JF , et al; French Center-East Internists Group; French Vasculitis Study Group. Urogenital manifestations in Wegener granulomatosis: a study of 11 cases and review of the literature. Medicine (Baltimore) 2012; 91 (2) 67-74
• 25 Mizunoe S, Yamasaki T, Tokimatsu I , et al. Sarcoidosis associated with renal masses on computed tomography. Intern Med 2006; 45 (5) 279-282
• 26 Mizushima I, Yamada K, Fujii H , et al. Clinical and histological changes associated with corticosteroid therapy in IgG4-related tubulointerstitial nephritis. Mod Rheumatol 2012; 22 (6) 859-870
• 27 Yamaguchi Y, Kanetsuna Y, Honda K, Yamanaka N, Kawano M, Nagata M ; Japanese study group on IgG4-related nephropathy. Characteristic tubulointerstitial nephritis in IgG4-related disease. Hum Pathol 2012; 43 (4) 536-549
• 28 Raissian Y, Nasr SH, Larsen CP , et al. Diagnosis of IgG4-related tubulointerstitial nephritis. J Am Soc Nephrol 2011; 22 (7) 1343-1352
• 29 Saeki T, Kawano M, Mizushima I , et al. The clinical course of patients with IgG4-related kidney disease. Kidney Int 2013; 84 (4) 826-833
• 30 Zen Y, Onodera M, Inoue D , et al. Retroperitoneal fibrosis: a clinicopathologic study with respect to immunoglobulin G4. Am J Surg Pathol 2009; 33 (12) 1833-1839
• 31 Yamashita K, Haga H, Mikami Y , et al. Degree of IgG4+ plasma cell infiltration in retroperitoneal fibrosis with or without multifocal fibrosclerosis. Histopathology 2008; 52 (3) 404-409
• 32 Vaglio A, Palmisano A, Alberici F , et al. Prednisone versus tamoxifen in patients with idiopathic retroperitoneal fibrosis: an open-label randomised controlled trial. Lancet 2011; 378 (9788) 338-346
• 33 Khosroshahi A, Carruthers MN, Stone JH , et al. Rethinking Ormond's disease: “idiopathic” retroperitoneal fibrosis in the era of IgG4-related disease. Medicine (Baltimore) 2013; 92 (2) 82-91
• 34 Mizushima I, Inoue D, Yamamoto M , et al. Clinical course after corticosteroid therapy in IgG4-related aortitis/periaortitis and periarteritis: a retrospective multicenter study. Arthritis Res Ther 2014; 16 (4) R156
• 35 Maleszewski JJ, Tazelaar HD, Horcher HM , et al. IgG4-related disease of the aortic valve: a report of two cases and review of the literature. Cardiovasc Pathol 2015; 24 (1) 56-59
• 36 Bito Y, Sasaki Y, Hirai H , et al. A surgical case of expanding bilateral coronary aneurysms regarded as immunoglobulin G4-related disease. Circulation 2014; 129 (16) e453-e456
• 37 Yanagi H, Yamazaki I, Shimizu S, Himeno H, Suzuki S, Masuda M. Constrictive pericarditis caused by immunoglobulin G4-related disease. Ann Thorac Surg 2014; 97 (3) e71-e74
• 38 Ikutomi M, Matsumura T, Iwata H , et al. Giant tumorous lesions (correction of legions) surrounding the right coronary artery associated with immunoglobulin-G4-related systemic disease. Cardiology 2011; 120 (1) 22-26
• 39 Urabe Y, Fujii T, Kurushima S, Tsujiyama S, Kihara Y. Pigs-in-a-blanket coronary arteries: a case of immunoglobulin G4-related coronary periarteritis assessed by computed tomography coronary angiography, intravascular ultrasound, and positron emission tomography. Circ Cardiovasc Imaging 2012; 5 (5) 685-687
• 40 Gutierrez PS, Schultz T, Siqueira SA, de Figueiredo Borges L. Sudden coronary death due to IgG4-related disease. Cardiovasc Pathol 2013; 22 (6) 505-507
• 41 Holmes BJ, Delev NG, Pasternack GR, Halushka MK. Novel cause of sudden cardiac death: IgG4-related disease. Circulation 2012; 125 (23) 2956-2957
• 42 Sugimoto T, Morita Y, Isshiki K , et al. Constrictive pericarditis as an emerging manifestation of hyper-IgG4 disease. Int J Cardiol 2008; 130 (3) e100-e101
• 43 Matsui S, Hebisawa A, Sakai F , et al. Immunoglobulin G4-related lung disease: clinicoradiological and pathological features. Respirology 2013; 18 (3) 480-487
• 44 Yamamoto H, Yasuo M, Ito M , et al. Clinical features of central airway involvement in autoimmune pancreatitis. Eur Respir J 2011; 38 (5) 1233-1236
• 45 Matsui S, Taki H, Shinoda K , et al. Respiratory involvement in IgG4-related Mikulicz's disease. Mod Rheumatol 2012; 22 (1) 31-39
• 46 Yamamoto M, Takahashi H, Ohara M , et al. A case of Mikulicz's disease (IgG4-related plasmacytic disease) complicated by autoimmune hypophysitis. Scand J Rheumatol 2006; 35 (5) 410-411
• 47 Shimatsu A, Oki Y, Fujisawa I, Sano T. Pituitary and stalk lesions (infundibulo-hypophysitis) associated with immunoglobulin G4-related systemic disease: an emerging clinical entity. Endocr J 2009; 56 (9) 1033-1041
• 48 Leporati P, Landek-Salgado MA, Lupi I, Chiovato L, Caturegli P. IgG4-related hypophysitis: a new addition to the hypophysitis spectrum. J Clin Endocrinol Metab 2011; 96 (7) 1971-1980
• 49 Nishioka H, Shibuya M, Haraoka J. Immunohistochemical study for IgG4-positive plasmacytes in pituitary inflammatory lesions. Endocr Pathol 2010; 21 (4) 236-241
• 50 Li Y, Nishihara E, Hirokawa M, Taniguchi E, Miyauchi A, Kakudo K. Distinct clinical, serological, and sonographic characteristics of Hashimoto's thyroiditis based with and without IgG4-positive plasma cells. J Clin Endocrinol Metab 2010; 95 (3) 1309-1317
• 51 Kojima M, Hirokawa M, Kuma H , et al. Distribution of IgG4- and/or IgG-positive plasma cells in Hashimoto's thyroiditis: an immunohistochemical study. Pathobiology 2010; 77 (5) 267-272
• 52 Li Y, Nishihara E, Kakudo K. Hashimoto's thyroiditis: old concepts and new insights. Curr Opin Rheumatol 2011; 23 (1) 102-107
• 53 Vickery AL, Hamlin Jr E. Struma lymphomatosa (Hashimoto's thyroiditis). Observations on repeated biopsies in sixteen patients. N Engl J Med 1961; 264: 226-229
• 54 Hennessey JV. Clinical review: Riedel's thyroiditis: a clinical review. J Clin Endocrinol Metab 2011; 96 (10) 3031-3041
• 55 Yoshimura Y, Takeda S, Ieki Y, Takazakura E, Koizumi H, Takagawa K. IgG4-associated prostatitis complicating autoimmune pancreatitis. Intern Med 2006; 45 (15) 897-901
• 56 Uehara T, Hamano H, Kawakami M , et al. Autoimmune pancreatitis-associated prostatitis: distinct clinicopathological entity. Pathol Int 2008; 58 (2) 118-125
• 57 Umehara H, Okazaki K, Masaki Y , et al. Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011. Mod Rheumatol 2012; 22 (1) 21-30
• 58 Yamamoto M, Nojima M, Takahashi H , et al. Identification of relapse predictors in IgG4-related disease using multivariate analysis of clinical data at the first visit and initial treatment. Rheumatology (Oxford) 2015; 54 (1) 45-49