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Am J Perinatol 2016; 33(10): 998-1002
DOI: 10.1055/s-0036-1583189
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Association between Hemoglobin Levels in the First 3 Days of Life and Bronchopulmonary Dysplasia in Preterm Infants

Jun Duan
1   Department of Pediatrics, BaYi Children's Hospital Affiliated to Clinical Medical College in Beijing Military General Hospital, Southern Medical University, Beijing, China
,
Xiangyong Kong
1   Department of Pediatrics, BaYi Children's Hospital Affiliated to Clinical Medical College in Beijing Military General Hospital, Southern Medical University, Beijing, China
,
Qiuping Li
1   Department of Pediatrics, BaYi Children's Hospital Affiliated to Clinical Medical College in Beijing Military General Hospital, Southern Medical University, Beijing, China
,
Shaodong Hua
1   Department of Pediatrics, BaYi Children's Hospital Affiliated to Clinical Medical College in Beijing Military General Hospital, Southern Medical University, Beijing, China
,
Sheng Zhang
1   Department of Pediatrics, BaYi Children's Hospital Affiliated to Clinical Medical College in Beijing Military General Hospital, Southern Medical University, Beijing, China
,
Zhichun Feng
1   Department of Pediatrics, BaYi Children's Hospital Affiliated to Clinical Medical College in Beijing Military General Hospital, Southern Medical University, Beijing, China
,
Xiaoying Zhang
1   Department of Pediatrics, BaYi Children's Hospital Affiliated to Clinical Medical College in Beijing Military General Hospital, Southern Medical University, Beijing, China
› Author Affiliations
Further Information

Publication History

27 November 2015

14 March 2016

Publication Date:
27 April 2016 (online)

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Abstract

Objective The objective of this study was to determine the association between hemoglobin (Hb) levels in the first 3 days of life and bronchopulmonary dysplasia (BPD) in preterm infants.

Study Design The study population comprises 147 neonates with a gestational age (GA) of less than 32 weeks who were admitted to BaYi Children's Hospital Affiliated to Beijing Military General Hospital from January 2014 to May 2015. Hb levels in the first 3 days of life, maternal and infant characteristics, were recorded and then analyzed.

Results BPD patients had a lower GA and birth weight than non-BPD patients. Rates of surfactant use, use of early inhalation hormone, days of mechanical ventilation > 2 weeks, and patent ductus arteriosus in BPD patients were higher and have a significant difference. Number of transfusions was higher in BPD patients. Lower Hb levels in the first 3 days of life were also observed in BPD patients. A cutoff value of Hb levels was determined as 155.5 g/L. Hb ≤ 155 g/L in the first 3 days of life was a significant risk factor for BPD.

Conclusion Our study demonstrated that lower Hb levels in the first 3 days of life may increase the risk of developing BPD in preterm infants.

Keywords

bronchopulmonary dysplasia - hemoglobin levels - preterm infants - transfusion
 

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