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Thorac Cardiovasc Surg 2016; 64(01): 053-058
DOI: 10.1055/s-0035-1566235
Original Cardiovascular
Georg Thieme Verlag KG Stuttgart · New York

Custodiol Solution and Cold Blood Cardioplegia in Arterial Switch Operation: Retrospective Analysis in a Single Center

Raffaele Giordano
1   Department of Pediatric Cardiology and Cardiac Surgery, Tuscany Foundation “G. Monasterio,” Massa, MS, Italy
,
Luigi Arcieri
1   Department of Pediatric Cardiology and Cardiac Surgery, Tuscany Foundation “G. Monasterio,” Massa, MS, Italy
,
Massimiliano Cantinotti
1   Department of Pediatric Cardiology and Cardiac Surgery, Tuscany Foundation “G. Monasterio,” Massa, MS, Italy
,
Vitali Pak
1   Department of Pediatric Cardiology and Cardiac Surgery, Tuscany Foundation “G. Monasterio,” Massa, MS, Italy
,
Vincenzo Poli
1   Department of Pediatric Cardiology and Cardiac Surgery, Tuscany Foundation “G. Monasterio,” Massa, MS, Italy
,
Anna Maizza
1   Department of Pediatric Cardiology and Cardiac Surgery, Tuscany Foundation “G. Monasterio,” Massa, MS, Italy
,
Manuel Melo
1   Department of Pediatric Cardiology and Cardiac Surgery, Tuscany Foundation “G. Monasterio,” Massa, MS, Italy
,
Nadia Assanta
1   Department of Pediatric Cardiology and Cardiac Surgery, Tuscany Foundation “G. Monasterio,” Massa, MS, Italy
,
Riccardo Moschetti
1   Department of Pediatric Cardiology and Cardiac Surgery, Tuscany Foundation “G. Monasterio,” Massa, MS, Italy
,
Bruno Murzi
1   Department of Pediatric Cardiology and Cardiac Surgery, Tuscany Foundation “G. Monasterio,” Massa, MS, Italy
› Author Affiliations
Further Information

Publication History

30 July 2015

16 September 2015

Publication Date:
24 November 2015 (online)

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Abstract

Background The cardioplegia is one of the most significant tools used to increase myocardial protection. The aim of our study is to compare the use of Custodiol solution versus intermitted blood cardioplegia in a retrospective analysis of data for patients who underwent arterial switch operation in our institution.

Material and Methods From January 2008 to March 2011, myocardial protection was performed in 44 neonates (blood group) with intermittent blood cardioplegia. From March 2011 to November 2014, myocardial protection was performed in 50 neonates (Custodiol group) with one-shot anterograde Custodiol cardioplegia.

Results Cardiopulmonary bypass and aortic cross-clamp were more favorable in Custodiol group (p-value 0.005 and ≤ 0.00001). The rate of delayed sternal closure was 63.6% in the blood group and 52% in the Custodiol group (p = 0.25). In the postoperative outcomes we did not find differences between the two groups. The 30-day mortality was one patient in the blood group (p = 0.46). We observed a transient ischemic electrocardiogram in 10 patients of the blood group and in 14 of the Custodiol group (p = 0.72), all cases with full resolution during hospitalization without coronary reoperation. A trend of higher peak of troponin-I and brain natriuretic peptide in Custodiol group has been reported.

Conclusion No prefect cardioplegia exists, the Custodiol solution does not cause extra/additional myocardial damage in arterial switch operation. In our experience this strategy seems warranted to simplify the procedure and to be more comfortable for the surgeon.

Keywords

cardiopulmonary bypass - congenital heart disease - perfusion - pediatric
 

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