Enantioselective Addition of Organoboron Reagents to Fluoroketones
Catalytic Enantioselective Addition of Organoboron Reagents to Fluoroketones Controlled by Electrostatic Interactions.
Nature Chem. 2016;
19 July 2016 (online)
Hoveyda and co-workers have developed an efficient catalytic method for the addition of allyl and allenyl organoboron reagents to fluoroketones, leading to trifluoromethyl-substituted tertiary alcohols in up to 98% yield.
The versatility of the presented method is illustrated in an enantioselective route to the antiparasitic drug fluralaner (Bravecto, Merck).