A new tandem process is reported that provides access to α-hydroxyamides from epoxides
for the first time. Herein, we explore InCl3-mediated tandem rearrangement of epoxides to aldehydes and α-addition of TosMIC to
in situ derived aldehydes. An unprecedented C–C bond-forming reaction is disclosed
that features mild conditions, high yields, and shorter reaction times.
Key words
C–C bond formation - indium(III) chloride - epoxides - TosMIC - tandem rearrangement
- α-addition