Asymmetric Carbonyl Reduction with a Supported Ketoreductase
Development of an Immobilized Ketoreductase for Enzymatic (R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethanol Production.
Org. Process Res. Dev. 2015;
18 September 2015 (online)
Immobilized ketoreductase P1B2 (immob P1B2), prepared as shown in eq. 1, catalyzed the asymmetric transfer-hydrogenation of ketones in 90:10 propan-2-ol–water to give the corresponding alcohols in up to 100% conversion and up to >99% ee (eq. 2). This reaction was used in a 50 g scale reduction of 3,5-[bis(trifluoromethyl)phenyl]ethanone (1) (eq. 3).
Immob P1B2 was recovered and reused nine times without any loss of its catalytic performance. The catalyst was also used in a flow transfer hydrogenation of ketone 1.