The Genetics of Urinary Tract Infections and the Innate Defense of the Kidney and Urinary tract

Ines Ambite; Gustav Rydstrom; Andrew L. Schwaderer; David S. Hains

doi:10.1055/s-0035-1557110

Journal of Pediatric Genetics, Inhaltsverzeichnis

J Pediatr Genet 2016; 05(01): 025-032
DOI: 10.1055/s-0035-1557110

Review Article

Georg Thieme Verlag KG Stuttgart · New York

The Genetics of Urinary Tract Infections and the Innate Defense of the Kidney and Urinary tract

Ines Ambite^*

¹Section of Microbiology, Immunology and Glycobiology, Institute of Laboratory Medicine, Lund University, Lund, Sweden

,

Gustav Rydstrom^*

¹Section of Microbiology, Immunology and Glycobiology, Institute of Laboratory Medicine, Lund University, Lund, Sweden

,

Andrew L. Schwaderer

²Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, United States

,

David S. Hains

³Children's Foundation Research Institute at Le Bonheur Children's Hospital, Memphis, Tennessee, United States

⁴Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, United States

› Institutsangaben

Abstract

The urinary tract is a sterile organ system. Urinary tract infections (UTIs) are common and often serious infections. Research has focused on uropathogen, environment, and host factors leading to UTI pathogenesis. A growing body of evidence exists implicating genetic factors that can contribute to UTI risks. In this review, we highlight genetic variations in aspects of the innate immune system critical to the host response to uropathogens. This overview includes genetic variations in pattern recognition receptor molecules, chemokines/cytokines, and neutrophil activation. We also comprehensively cover murine knockout models of UTI, genetic variations involved in renal scarring as a result of ascending UTIs, and asymptomatic bacteriuria.

Keywords

innate immunity - genetics - urinary tract infections - asymptomatic bacteriuria

Volltext

Referenzen

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