Abstract
Delivery of medication to sites of action through airways has been used for centuries
but has gained momentum in recent decades. Currently available modes of aerosol delivery
offer advantages but still there are shortcomings. Delivery of active agents to sites
of action is affected by many factors beyond the characteristics of the delivery devices,
including the coordination between inhalation and actuation and dependence on the
patient's inspiratory flow and breathing pattern. Recent advances in drug delivery
focus around changes in the generation of particle size with better penetration to
the targeted sites, easier activation of the device with inspiratory flow, ease of
use including fewer steps in using the device, and better portability. Availability
of computer chips allows for smart delivery devices to tailor delivery to the patient's
breathing pattern and lung function. Further, smart devices can provide feedback to
patients. Novel inhaler technologies, separately or in combination with new therapeutic
agents, are in development not only for respiratory diseases but also for diseases
of other systems. This article reviews some of the recent clinically relevant advances
in aerosol delivery devices.
Keywords
drug delivery - aerosol - nebulizer - particle size
