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Semin Thromb Hemost 2015; 41(07): 802-808
DOI: 10.1055/s-0034-1544004
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Newer Hemostatic Agents

Massimo Franchini
1   Department of Hematology and Transfusion Medicine, Azienda Ospedaliera Carlo Poma, Mantova, Italy
,
Emmanuel J. Favaloro
2   Department of Haematology, Institute of Clinical Pathology and Medical Research (ICPMR), Pathology West, Westmead Hospital, Westmead, New South Wales, Australia
,
Giuseppe Lippi
3   Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma, Italy
› Author Affiliations
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Publication History

Publication Date:
20 April 2015 (online)

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Abstract

The mainstay of treatment of inherited coagulation disorders is based on the infusion of the deficient clotting factor, when available. Significant advances have been made over the past two decades in the production and availability of factor replacement products. In spite of such progression, several issue are still unsolved, the most important being the need for frequent factor concentrate infusions and the development of inhibitory alloantibodies. To overcome these important limitations, several newer hemostatic agents with an extended half-life are at an advanced stage of clinical development. After a brief overview of hemostasis, this narrative review summarizes the current knowledge on the most promising novel products for hemostasis. The current status of gene therapy for hemophilia, the only therapeutic option to definitively cure this inherited bleeding disorder, is also concisely discussed.

Keywords

clotting factor concentrates - new hemostatic products - extended half-life - hemophilia - inhibitors
 

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