Endoskopie heute 2015; 28(01): 20-25
DOI: 10.1055/s-0034-1399205
Originalarbeit

Breitflächige Duodenal- und Papillenadenome – eine Herausforderung im Grenzbereich zwischen interventioneller Endoskopie und Chirurgie

Giant Lateral Spreading Duodenal and Papillary Adenoma – a Therapeutic Challenge between Interventional Endoscopy and Surgery
S. Seewald
1   GastroZentrum, Klinik Hirslanden Zürich
,
P. Bertschinger
1   GastroZentrum, Klinik Hirslanden Zürich
,
A. L. Jacob
2   Zentrum für Mikrotherapie, Klinik Hirslanden Zürich
,
J. Schmidt
3   Chirurgisches Zentrum Zürich, Klinik Hirslanden Zürich
› Author Affiliations

Zusammenfassung

Die Resektion von breitflächigen Duodenal- und Papillenadenomen gehört zu den endoskopischen Eingriffen mit einem deutlich erhöhten Komplikationsrisiko. Die Indikationsstellung für eine endoskopische Resektion bedarf deshalb einer spezifischen Risikoabschätzung. Chirurgische Verfahren wie die pankreaserhaltende Duodenektomie oder transduodenale Papillekomie sind dabei mögliche Alternativen. Der folgende Artikel gibt einen Überblick über die aktuellen endoskopischen und chirurgischen Verfahren. Des Weiteren werden wichtige praktische Aspekte des klinischen Managements, der Diagnostik und Therapie mit Beispielen diskutiert.

Abstract

Endoscopic resection of giant duodenal and papillary adenoma is associated with a significant higher complication rate. Therefore the indication of an endoscopic resection requires a specific preinterventional risk analysis. Surgical techniques such as pancreas-preserving duodenectomy and transduodenal local excisions of tumors of the papilla of Vater are potential alternatives. The following article describes the latest endoscopic and surgical techniques. Furthermore, important practical aspects of the endoscopic assessment, therapy and the clinical management are discussed.



Publication History

Publication Date:
23 March 2015 (online)

© 2015. Thieme. All rights reserved.

Georg Thieme Verlag KG
Stuttgart · New York

 
  • Literatur

  • 1 Yamamoto H, Miura Y. Duodenal ESD: Conquering difficulties. Gastrointestinal Endoscopy Clin N Am 2014; 24: 235-244
  • 2 Kakushima N, Ono H, Takao T. et al. Method and timing of resection of superficial non-ampullary duodenal epithelial tumors. Digestive Endoscopy 2014; 26 (Suppl. 02) 35-40
  • 3 Hoteya S, Kaise M, Iizuka T. et al. Delayed bleeding after endoscopic submucosal diissection for non-ampullary superficial duodenal neoplasias might be prevented by prophylactic endoscopic closure: Analysis of risk factors. Digestive endoscopy 2015; 27 (03) 323-330
  • 4 Mirsadraee S, Tirukonda P, Nicholson A. et al. Embolization for non-variceal upper gastrointestinal tract haemorrhage: a systematic review. Clinical Radiology 2011; 66 (06) 500-509
  • 5 Mirjalili SA, Stringer MD. The arterial supply of the major duodenal papilla and its relevance to endoscopic sphincterotomy. Endoscopy 2011; 43 (04) 307-311
  • 6 Napoleon B, Rodica G, Ponchon T. et al. Endoscopic papillectomy for early ampullary tumors: long-term results from a large multicenter prospective study. Endoscopy 2014; 46: 127-134
  • 7 Bohnacker S, Seitz U, Nguyen D. et al. Endoscopic resection of benign tumors of the duodenal papilla without and with intraductal growth. Gastrointest Endosc 2005; 62 (04) 551-560
  • 8 Fanning SB, Bourke MJ, Williams SJ. et al. Giant laterally spreading tumors of the duodenum: endoscopic resection outcomes, limitations, and caveats. Gastrointestinal Endosc 2012; 75: 805-812
  • 9 Alexander S, Bourke MJ, Williams SJ. EMR of large, sessile, sporadic non ampullary duodenal adenomas: technical aspects and long term outcome (with videos). Gastrointestinal Endosc 2009; 69: 66-73
  • 10 Hopper AD, Bourke MJ, Williams SJ. Giant laterally spreading tumors of the papilla: endoscopic features, resection technique, and outcome (with videos). Gastrointestinal Endosc 2010; 71: 967-975
  • 11 Nonaka S, Oda I, Tada K. et al. Clinical outcome of endoscopic resection for nonampullary duodenal tumors. Endoscopy 2015; 47 (02) 129-135
  • 12 Rangelova E, Blomberg J, Ansorge C. et al. Pancreas-preserving duodenectomy is a safe alternative to high-risk pancreatoduodenectomy for premalignant duodenal lesions. J Gastrointest Surg 2015; 19 (03) 492-497
  • 13 Paramythiotis D, Kleeff J, Wirtz M. et al. Still any role for transduodenal local excision in tumors of the papilla of Vater?. J Hepatobiliary Pancreat Surg 2004; 11 (04) 239-244
  • 14 Lee S, Kim SW, Moon JC. Early angiographic embolization is more effective than delayed angiographic embolization in patients with duodenal ulcer bleeding. Journal of gastroenterology and hepatology 2012; 27 (11) 1670-1674
  • 15 Loffroy R, Rao P, Ota S. Embolization of acute nonvariceal upper gastrointestinal hemorrhage resistant to endoscopic treatment: results and predictors of recurrent bleeding. Cardiovascular and interventional radiology 2010; 33 (06) 1088-1100