Endoskopie heute 2014; 27(04): 211-215
DOI: 10.1055/s-0034-1385790
Originalarbeit
© Georg Thieme Verlag KG Stuttgart · New York

Kolorektale (serratierte) Läsionen im Spannungsfeld zwischen Vorsorge und Nachsorge

Colorectal (Serrated) Lesions in Between the Poles of Prevention and Follow-up
M. Vieth
1   Institut für Pathologie, Klinikum Bayreuth, Bayreuth
,
H. Neumann
2   Klinik für Innere Medizin I, Universität Erlangen, Erlangen
› Author Affiliations
Further Information

Publication History

Publication Date:
27 January 2015 (online)

Zusammenfassung

Die Möglichkeit zur Vorsorgekoloskopie wird in Deutschland nicht ausreichend wahrgenommen. Die Gründe sind vielschichtig. Neue Techniken verbessern die Visualisierung von kolorekalen Läsionen. Dies ist umso wichtiger, da gerade flache serratierte Läsionen mit den herkömmlichen Endoskopen schwer zu entdecken und gegen die Umgebung abgrenzbar sind. Leider ist die Terminologie der serratierten Läsionen verwirrend. Umso wichtiger ist das Wissen um die Begrifflichkeiten. Die Historie der Entwicklung der Begriffe ist hier möglicherweise hilfreich, um das Potenzial der Möglichkeiten zur Risikobestimmung durch die Histopathologie voll auszuschöpfen.

Abstract

Preventive colonoscopy is lot less performed in Germany than needed. Various reasons apply. New techniques improve visualisation of colorectal lesions. This is especially important since flat serrated lesions can be hard to detect and delinate. Unfortunately the terminology of serrated lesions is confusing. Therefore it is important to know more about the terms used. The historical development of the terms may help to fuel the potential of the possibilities of histopathology for risk stratification.

 
  • Literatur

  • 1 Robert Koch-Institut (Hrsg) und die Gesellschaft der epidemiologischen Krebsregister in Deutschland e. V. (Hrsg). Krebs in Deutschland 2007/2008. 8. Ausgabe. Berlin: 2012
  • 2 Leitlinienprogramm Onkologie (Deutsche Krebsgesellschaft, Deutsche Krebshilfe, AWMF). S3-Leitlinie Kolorektales Karzinom, Langversion 1.0, AWMF Registrierungsnummer: 021-007OL. http://leitlinienprogramm-onkologie.de/Leitlinien.7.0.html
  • 3 Shaukat A, Mongin SJ, Geisser MS et al. Long-term mortality after screening for colorectal cancer. N Engl J Med 2013; 369 (12) 1106-1114 DOI: 10.1056/NEJMoa1300720.
  • 4 Siegel R, Desantis C, Jemal A. Colorectal cancer statistics, 2014. CA Cancer J Clin 2014; 64 (02) 104-117 DOI: 10.3322/caac.21220.
  • 5 Schäfer M, Altenhofen L, Graf von Stillfried D. Darmkrebsprävention: Teilnahmeraten stagnieren – mehr Information erforderlich. Dtsch Arztebl 2012; 109 (11) A528/B-452/C-448
  • 6 Ferlitsch M, Reinhart K, Pramhas S et al. Sex-specific prevalence of adenomas, advanced adenomas, and colorectal cancer in individuals undergoing screening colonoscopy. JAMA 2011; 306 (12) 1352-1358 DOI: 10.1001/jama.2011.1362.
  • 7 Kolligs FT, Crispin A, Munte A et al. Risk of advanced colorectal neoplasia according to age and gender. PLoS One 2011; 6 (05) e20076 DOI: 10.1371/journal.pone.0020076. Epub 2011 May 24
  • 8 Ma Y, Yang Y, Wang F et al. Obesity and risk of colorectal cancer: a systematic review of prospective studies. PLoS One 2013; 8 (01) e53916 DOI: 10.1371/journal.pone.0053916. , Epub 2013 Jan 17. Review
  • 9 Abreu MT, Peek Jr RM. Gastrointestinal malignancy and the microbiome. Gastroenterology 2014; 146 (06) 1534-1546.e3 DOI: 10.1053/j.gastro.2014.01.001. , Epub 2014 Jan 7. Review
  • 10 Waye JD, Heigh RI, Fleischer DE et al. A retrograde-viewing device improves detection of adenomas in the colon: a prospective efficacy evaluation (with videos). Gastrointest Endosc 2010; 71: 551-556
  • 11 Halpern Z, Ishaq S, Neumann H et al. Su1210 G-EYE Colonoscopy Significantly Improves Adenoma Detection Rates – Initial Results of a Multicenter Prospective Cohort Study. Gastroenterology 2014; 146 (05) S-402 DOI: http://dx.doi.org/10.1016/S0016-5085(14)61456-6.
  • 12 Gralnek IM, Siersema PD, al Halpern Z. Standard forward-viewing colonoscopy versus full-spectrum endoscopy: an international, multicentre, randomised, tandem colonoscopy trial. Lancet Oncol 2014; 15: 353-360
  • 13 Vieth M, Langner C. (K)Eine Verwirrung um serratierte Kolonpolypen. J Gastroenterol Hepatol Erkr 2010; 8 (04) 7-12
  • 14 Preston SL, Wong WM, Chan AO et al. Bottom-up histogenesis of colorectal adenomas: origin in the monocryptal adenoma and initial expansion by crypt fission. Cancer Res 2003; 63 (13) 3819-3825
  • 15 Shih IM, Wang TL, Traverso G et al. Top-down morphogenesis of colorectal tumors. Proc Natl Acad Sci U S A 2001; 98 (05) 2640-2645
  • 16 Davis H, Irshad S, Bansal M et al. Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside of the crypt base stem cell niche. N Engl J Med 2014/2015 in press
  • 17 Schwitalla S, Fingerle AA, Cammareri P et al. Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell 2013; 152 (01) 25-38
  • 18 Vieth M, Neumann H. Current issues in IBD neoplasia. Histopathology 2014; DOI: 10.1111/his.12565. , [Epub ahead of print]
  • 19 Jass JR. Classification of colorectal cancer based on correlation of clinical, morphological and molecular features. Histopathology 2007; 50 (01) 113-130 , Review
  • 20 Bosmann FT, Carneiro F, Hruban RH (Hrsg). WHO Classification of tumours of the the digestive system. Lyon: IARC Press; 2010
  • 21 Payne SR, Church TR, Wandell M et al. Endoscopic detection of proximal serrated lesions and pathologic identification of sessile serrated adenomas/polyps vary on the basis of center. Clin Gastroenterol Hepatol 2014; 12 (07) 1119-1126 DOI: 10.1016/j.cgh.2013.11.034.
  • 22 Quirke P, Risio M, Lambert R et al. Quality assurance in pathology in colorectal cancer screening and diagnosis – European recommendations. Virchows Arch 2011; 458 (01) 1-19 DOI: 10.1007/s00428-010-0977-6. , Review
  • 23 Vieth M, Quirke P, Lambert R et al. Annex to Quirke et al. Quality assurance in pathology in colorectal cancer screening and diagnosis: annotations of colorectal lesions. Virchows Arch 2011; 458 (01) 21-30 DOI: 10.1007/s00428-010-0997-2. , Review
  • 24 Bayar S, Saxena R, Emir B et al. Venous invasion may predict lymph node metastasis in early rectal cancer. Eur J Surg Oncol 2002; 28 (04) 413-417
  • 25 Suzuki A, Togashi K, Nokubi M et al. Evaluation of venous invasion by Elastica van Gieson stain and tumor budding predicts local and distant metastases in patients with T1 stage colorectal cancer. Am J Surg Pathol 2009; 33 (11) 1601-1607 DOI: 10.1097/PAS.0b013e3181ae29d6.
  • 26 Rogers AC, Gibbons D, Hanly AM et al. Prognostic significance of tumor budding in rectal cancer biopsies before neoadjuvant therapy. Mod Pathol 2014; 27 (01) 156-162 DOI: 10.1038/modpathol.2013.124.
  • 27 Baretton GB, Autschbach F, Baldus S et al. Histopathological diagnosis and differential diagnosis of colorectal serrated polys: findings of a consensus conference of the working group „gastroenterological pathology of the German Society of Pathology“. Pathologe 2011; 32 (01) 76-82 DOI: 10.1007/s00292-010-1365-3. , Review