Planta Med 2014; 80(15): 1298-1303
DOI: 10.1055/s-0034-1382995
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Meroterpenes from Psoralea corylifolia against Pyricularia oryzae

Youwu Huang
1   School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China
,
Xiaoyu Liu
2   Department of Biological Chemistry, Second Military Medicinal University, Shanghai, P. R. China
,
Yingchun Wu
1   School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China
,
Yiming Li
1   School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China
,
Fujiang Guo
1   School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China
› Author Affiliations
Further Information

Publication History

received 12 March 2014
revised 10 July 2014

accepted 21 July 2014

Publication Date:
15 August 2014 (online)

Abstract

Six new meroterpenes, namely, 13-methoxyisobakuchiol (1), 13-ethoxyisobakuchiol (2), 12,13-dihydro-13-hydroxybakuchiol (3), Δ10-12,13-dihydro-12-(R,S)-methoxyisobakuchiol (4 and 5), and 15-demetyl-12,13-dihydro-13-ketobakuchiol (6), together with four known ones, namely, Δ3,2-hydroxybakuchiol (7), Δ1,3-hydroxybakuchiol (8), bakuchiol (9), and Δ1,3-bakuchiol (10), were isolated from the seeds of Psoralea corylifolia. Their structures were identified based on spectral data, including those obtained via 1D and 2D NMR, and MS spectral analyses. Antifungal screening results indicated that all compounds showed moderate inhibitory activities against Pyricularia oryzae.

These authors contributed equally to this paper.


 
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