Depside α-Glucosidase Inhibitors from a Culture of the Mushroom Stereum hirsutum

Abstract

Nine new isoprenylated depsides, sterenins E–M (1–9), as well as five known compounds (10–14), were isolated from the solid culture of Stereum hirsutum. The structures of the new compounds were elucidated by spectroscopic methods. Their inhibitory activities against yeast α-glucosidase were evaluated in vitro. Compounds 1–4 and 7–14 showed inhibitory activities with IC₅₀ values of 7.62, 3.06, 6.03, 22.70, 36.64, 13.09, 27.52, 25.10, 12.32, 3.31, 23.82, and 14.17 µM, respectively. Compounds 5 and 6 showed no inhibitory activities with IC₅₀ values higher than 50 µM. Therefore, the culture of S. hirsutum and its secondary metabolites could have a potential usage for the development of hypoglycemic drugs.

Key words

Stereum hirsutum - Stereaceae - isoprenylated phenols - structure elucidation - glucosidase inhibition

^* These authors contributed equally to this work.

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