Abstract
There has been increasing evidence that ascending thoracic aortic aneurysms (TAAs)
protect against atherosclerosis. However, there have been no studies examining the
relationship between ascending TAAs and clinical endpoints of atherosclerosis, such
as stroke or peripheral arterial disease. In this study, we aim to characterize the
relationship between TAAs and a specific clinical endpoint of atherosclerosis, myocardial
infarction (MI). We compared prevalence of coronary artery disease (CAD) and MIs in
487 patients who underwent surgical repair for ascending TAAs to 500 control patients
who did not have an ascending TAA. Multivariate binary logistic regression was used
to calculate the odds of having MI if a patient had an ascending TAA versus any of
several MI risk factors. There was a significantly lower prevalence of CAD and MI
in the ascending TAA group than in the control TAA group. The odds of having a MI
if a patient had a MI risk factor were all > 1 (more likely to have a MI), with the
lowest statistically significant odds ratio being 1.54 (age; p = 0.001) and the highest being 14.9 (family history of MI; p < 0.001). The odds ratio of having a MI if a patient had an ascending TAA, however,
was near 0 at 0.05 (p < 0.001). This study provides evidence that ascending TAAs protect against MIs, adding
further support to the hypothesis that ascending TAAs protect against atherosclerotic
disease.
Keywords
atherosclerosis - cardiovascular risk factors - coronary artery - myocardial infarction
- aneurysm - acute coronary syndrome - infarction
