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Synfacts 2015; 11(4): 0385
DOI: 10.1055/s-0034-1380398
DOI: 10.1055/s-0034-1380398
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
Enantioselective and Stereodivergent Synthesis of β,β-Diaryl-α-Amino Acids
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
18. März 2015 (online)
Significance
The β,β-diarylalanine core is a synthetically useful motif due to its prevalence in bioactive molecules. Merck process chemists demonstrate the elegant utility of asymmetric Rh-catalyzed hydrogenation to access such challenging structures.
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Comment
The authors report a three-step sequence with potential access to all four stereoisomers of the β,β-diarylalanines. A difficult to achieve hydrogenation on a tetrasubstituted olefin was effected using Rh catalysis with a chiral Josiphos ligand.
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