Pi C, Cui X, * Liu X, Guo M, Zhang H, Wu Y. * Zhengzhou University and Xiamen Key
Laboratory of Ocean and Gene Drugs, School of Biomedical Sciences and Institute of
Molecular Medicine of Huaqiao University & Engineering Research Center of Molecular
Medicine of Chinese Education Ministry, Xiamen, P. R. of China
Synthesis of Ferrocene Derivatives with Planar Chirality via Palladium-Catalyzed Enantioselective
C–H Bond Activation.
Org. Lett. 2014;
16: 5164-5167
Key words
enantioselective acylation - ferrocenes - palladium
Significance
The authors report a highly enantioselective route to the synthesis of 2-acyl-1-dimethylaminomethylferrocene
derivatives with planar chirality via a palladium-catalyzed asymmetric C–H bond activation
using monoprotected amino acids as chiral ligands.
Comment
Due to their important role in promoting various asymmetric catalyzed reactions, 2-acyl-1-dimethylaminomethylferrocene
derivatives with planar chirality were provided under one-pot reaction conditions
in moderate to good yields and with excellent enantioselectivities via a palladium-catalyzed
direct acylation of ferrocene.
