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Synfacts 2015; 11(1): 0049
DOI: 10.1055/s-0034-1379754
DOI: 10.1055/s-0034-1379754
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
Asymmetric Synthesis of Ferrocenes via Palladium-Catalyzed C–H Bond Activation
Pi C, Cui X, * Liu X, Guo M, Zhang H, Wu Y. * Zhengzhou University and Xiamen Key Laboratory of Ocean and Gene Drugs, School of Biomedical Sciences and Institute of Molecular Medicine of Huaqiao University & Engineering Research Center of Molecular Medicine of Chinese Education Ministry, Xiamen, P. R. of China
Synthesis of Ferrocene Derivatives with Planar Chirality via Palladium-Catalyzed Enantioselective C–H Bond Activation.
Org. Lett. 2014;
16: 5164-5167
Synthesis of Ferrocene Derivatives with Planar Chirality via Palladium-Catalyzed Enantioselective C–H Bond Activation.
Org. Lett. 2014;
16: 5164-5167
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
15. Dezember 2014 (online)
Significance
The authors report a highly enantioselective route to the synthesis of 2-acyl-1-dimethylaminomethylferrocene derivatives with planar chirality via a palladium-catalyzed asymmetric C–H bond activation using monoprotected amino acids as chiral ligands.
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Comment
Due to their important role in promoting various asymmetric catalyzed reactions, 2-acyl-1-dimethylaminomethylferrocene derivatives with planar chirality were provided under one-pot reaction conditions in moderate to good yields and with excellent enantioselectivities via a palladium-catalyzed direct acylation of ferrocene.
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