He P, Zheng H, Liu X, Lian X, Lin L, Feng X * Sichuan University, Chengdu, P. R. of China
Asymmetric Reduction of α-Amino Ketones with KBH
4 Solution Catalyzed by Chiral Lewis Acids.
Chem. Eur. J. 2014;
20: 13482-13486
Key words
amino ketones - reduction - nickel - scandium
Significance
The authors developed a metal-catalyzed asymmetric reduction of α-amino ketones using
KBH4 as hydride source. Under mild conditions, desired amino alcohols are obtained with
high enantioselectivities.
Comment
β-Amino alcohols are important structural motif in natural or pharmaceutical compounds.
The authors also presented a gram-scale version of this reaction and its possible
transition state.
