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Synfacts 2015; 11(1): 0110
DOI: 10.1055/s-0034-1379714
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York

N-Formylation of Amines Using Molybdate Sulfuric Acid

Contributor(s):
Yasuhiro Uozumi
,
Shuo Yan
Karami B, * Farahi M, Pam F. Yasouj University, Iran
A Green Protocol for the N-Formylation of Amines Using Molybdate Sulfuric Acid as a Reusable Solid Catalyst.

Tetrahedron Lett. 2014;
55: 6292-6296
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Further Information

Publication History

Publication Date:
15 December 2014 (online)

 
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Key words

N-formylation - orthoformates - amines - molybdate sulfuric acid

Significance

Molybdate sulfuric acid (MSA) catalyzed the N-formylation of amines with orthoformates to give the corresponding formamide derivatives in up to 95% yield (19 examples). In the N-formylation of aniline with triethyl orthoformate, the catalyst was recovered by filtration and reused three times with a slight loss of catalytic activity (1st reuse: 87% yield, 3rd reuse: 80% yield).


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Comment

The catalytic activity of MSA was superior to that of the other catalysts (ZnO, ZrOCl2, MgBr2, ZnCl2, and H2SO4).The authors have reported previously the preparation of molybdate sulfuric acid and its application to the synthesis of phenazines and quinoxalines (Polycycl. Aromat. Compd. 2011, 31, 97).


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