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Drug Res (Stuttg) 2015; 65(09): 457-462
DOI: 10.1055/s-0034-1376976
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Synthesis and Pharmacological Evaluation of New Chemical Entities from Ibuprofen as Novel Analgesic Candidates

A. Ahmadi
1   Department of Chemistry, Faculty of Science, Karaj Branch, Islamic Azad University, Karaj, Iran
,
N. Naderi
2   Department of Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
,
M. Daniali
1   Department of Chemistry, Faculty of Science, Karaj Branch, Islamic Azad University, Karaj, Iran
,
S. Kazemi
1   Department of Chemistry, Faculty of Science, Karaj Branch, Islamic Azad University, Karaj, Iran
,
S. Aazami
1   Department of Chemistry, Faculty of Science, Karaj Branch, Islamic Azad University, Karaj, Iran
,
N. Alizadeh
1   Department of Chemistry, Faculty of Science, Karaj Branch, Islamic Azad University, Karaj, Iran
,
B. Nahri-Niknafs
1   Department of Chemistry, Faculty of Science, Karaj Branch, Islamic Azad University, Karaj, Iran
› Author Affiliations
Further Information

Publication History

received 17 April 2014

accepted 05 May 2014

Publication Date:
28 May 2014 (online)

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Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are the first choice of drugs that are normally used for the treatment of pain and inflammation. Ibuprofen (I) and its analogues as the most widely used NSAIDs have been synthesized in recent years. In an effort to establish new candidates with improved analgesic properties, derivatives (II–VII) with substituted aromatic as well as aliphatic moieties were synthesized in this experiment and evaluated in formalin test with rats. The results were compared to ibuprofen and control groups. Findings indicated that derivatives with new alkylphenyl rings (VI and VII) had some similar or more analgesic activities relative to the control and ibuprofen groups, respectively; which could be justified as to more alkyl and phenyl groups instead of p-isobutylphenyl moiety in I.

Key words

NSAIDs - ibuprofen - analgesic - modified aromatic and aliphatic moieties
 

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