Abstract
Non-steroidal anti-inflammatory drugs (NSAIDs) are the first choice of drugs that
are normally used for the treatment of pain and inflammation. Ibuprofen (I) and its analogues as the most widely used NSAIDs have been synthesized in recent
years. In an effort to establish new candidates with improved analgesic properties,
derivatives (II–VII) with substituted aromatic as well as aliphatic moieties were synthesized in this
experiment and evaluated in formalin test with rats. The results were compared to
ibuprofen and control groups. Findings indicated that derivatives with new alkylphenyl
rings (VI and VII) had some similar or more analgesic activities relative to the control and ibuprofen
groups, respectively; which could be justified as to more alkyl and phenyl groups
instead of p-isobutylphenyl moiety in I.
Key words
NSAIDs - ibuprofen - analgesic - modified aromatic and aliphatic moieties