Untersuchung der Rolle von ApoE 4 auf den menschlichen Schluckakt

Diese Arbeit untersucht mithilfe des Sydney-Fragebogens zu oropharyngealen Dysphagien einen potenziellen Einfluss des ApoE-4-Polymorphismus auf dysphasische Symptome.

• Literatur

• 1 Corder EH, Lannfelt L, Viitanen M et al. Apolipoprotein E genotype determines survival in the oldest old (85 years or older) who have good cognition. Arch Neurol 1996; 53: 418-422
• 2 Schächter F, Faure-Delanef L, Guénot F et al. Genetic associations with human longevity at the APOE and ACE loci. Nat Genet 1994; 6: 29-32
• 3 Caselli RJ, Dueck AC, Oseborne D et al. Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect. N Engl J Med 2009; 361: 255-263
• 4 Holland G, Jayasekeran V, Pendleton N et al. Prevalence and symptom profiling of oropharyngeal dysphagia in a community dwelling of an elderly population: a self-reporting questionnaire survey. Dis Esophagus 2011; 24: 476-480
• 5 Singh M, Singh P, Jneja PW et al. SNP-SNP interactions within APOE gene influence plasma lipids in postmenopausal osteoporosis. Rheumatol Int 2011; 31: 421-423
• 6 Wallace KL, Middleton S, Cook IJ. Development and validation of a self-report symptom inventory to assess the severity of oral-pharyngeal dysphagia. Gastroenterology 2000; 118: 678-687
• 7 Plassman BL, Welsh KA, Helms M et al. Intelligence and education as predictors of cognitive state in late life: a 50-year follow-up. Neurology 1995; 45: 1446-1450
• 8 Wancata J, Alexandrowicz R, Marquart B et al. The criterion validity of the Geriatric Depression Scale: a systematic review. Acta Psychiatr Scand 2006  114: 398-410
• 9 Mentz H, Horan M, Payton A et al. Homozygosity in the ApoE 4 polymorphism is associated with dysphagic symptoms in older adults. Dis Esophagus 2013;