Planta Med 2014; 80(07): 590-598
DOI: 10.1055/s-0034-1368428
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic Triterpenoid Glycosides from the Roots of Camellia oleifera

Xia Li
1   College of Pharmaceutical Science, Soochow University, Suzhou, China
,
Jianping Zhao
2   National Center for Natural Products Research, and Department of Pharmacognosy, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, Mississippi, USA
,
Cuiping Peng
1   College of Pharmaceutical Science, Soochow University, Suzhou, China
,
Zhong Chen
1   College of Pharmaceutical Science, Soochow University, Suzhou, China
,
Yanli Liu
1   College of Pharmaceutical Science, Soochow University, Suzhou, China
,
Qiongming Xu
1   College of Pharmaceutical Science, Soochow University, Suzhou, China
2   National Center for Natural Products Research, and Department of Pharmacognosy, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, Mississippi, USA
,
Ikhlas A. Khan
1   College of Pharmaceutical Science, Soochow University, Suzhou, China
2   National Center for Natural Products Research, and Department of Pharmacognosy, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, Mississippi, USA
,
Shilin Yang
1   College of Pharmaceutical Science, Soochow University, Suzhou, China
› Author Affiliations
Further Information

Publication History

received 19 December 2013
revised 26 February 2014

accepted 20 March 2014

Publication Date:
19 May 2014 (online)

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Abstract

Eight new triterpenoid saponins, oleiferosides A–H (18), were isolated from the EtOH extract of the roots of Camellia oleifera. Their structures were elucidated by a combination of 1D and 2D NMR techniques, mass spectrometry, and chemical methods. All were characterized to be oleanane-type saponins with sugar moieties linked to C-3 of the aglycone. Cytotoxic activities of these saponins were evaluated against four human tumor cell lines (A549, B16, BEL-7402, and MCF-7) by using the MTT in vitro assay. Compound 3 exhibited potent cytotoxic activitiy against all the tested cell lines with IC50 values < 10 µM. Compounds 1, 2, 4, and 5 showed moderate cytotoxic activities toward the tested cell lines.

Supporting Information