Uveitis Masquerade Syndrome and Orbital Lymphoma: Two Challenging Diagnosis

Uveitis masquerade syndrome and orbital lymphoma are two entities that can mimic an inflammatory disease. In both conditions a delay in diagnosis can affect the vital prognosis. Uveitis masquerade syndrome is observed in up to 5 % of patients referred for uveitis at a tertiary center [1]. It represents a wide group of ocular manifestations which do not respond well to well conducted corticosteroids or immunosuppressive therapy. The pseudo-uveitis or masquerade syndrome includes tumoral eye diseases, paraneoplasic syndrome, degenerative eye diseases such as retinitis pigmentosa and metabolic diseases such as amyloidosis, ocular trauma or Schwarz syndrome.

• References

• 1 Rothova A, Ooijman F, Kerkhoff F et al. Uveitis masquerade syndromes. Ophthalmology 2001; 108: 386-399
• 2 Longmuir SQ, Syed NA, Boldt HC. Diffuse anterior retinoblastoma without retinal involvement. Ophthalmology 2010; 117: 2034-2038
• 3 Mora P, Gonzales S, Crafa P et al. Peculiar findings in a case of bilateral uveal pigmented lesions. Ocul Immunol Inflamm 2010; 18: 379-382
• 4 Murphy MA, Thirkill CE, Hart jr. WM. Paraneoplastic retinopathy: a novel autoantibody reaction associated with small-cell lung carcinoma. J Neuroophthalmol 1997; 17: 77-83
• 5 Thirkill CE, Tait RC, Tyler NK et al. Intraperitoneal cultivation of small-cell carcinoma induces expression of the retinal cancer-associated retinopathy antigen. Arch Ophthalmol 1993; 111: 974-978
• 6 Coupland SE, Damato B. Lymphomas involving the eye and the ocular adnexa. Curr Opin Ophthalmol 2006; 17: 523-531
• 7 Aryasit O, Preechawai P, Aui-Aree N. Clinical presentation, aetiology and prognosis of orbital apex syndrome. Orbit 2013; 32: 91-94