PET/CT bei CUP-Syndromen

Zusammenfassung

Die Diagnostik bei einer Krebserkrankung unbekannten Ursprungs (CUP-Syndrom) erfordert die interdisziplinäre Kooperation von Onkologen, Pathologen und bildgebenden Disziplinen. Hier werden diagnostische Konzepte und übliche Herausforderungen der Bildgebung dargestellt, bei denen der gezielte Einsatz von PET/CT-Untersuchungen helfen kann. FDG-PET/CT ist zu empfehlen bei Patienten mit lokalisiertem CUP-Syndrom, wenn die herkömmliche Diagnostik einschl. CT den Primarius nicht identifizieren konnte. Die Somatostatin-Rezeptor-PET/CT mit Ga-68-DOTA-konjugierten Peptiden ergänzt die Diagnostik bei CUP-Syndromen mit neuroendokrinen Tumoren.

Abstract

The diagnostic work-up of patients with cancer of unknown primary sites (CUP syndrome) requires the close cooperation between oncologists, pathologists and of imaging disciplines. Here the diagnostic concepts and frequent challenges for the imaging modalities are presented in which PET/CT examinations may help. FDG-PET/CT is recommended in patients with localized CUP syndrome if conventional work-up including CT failed to identify the primary tumour. Somatostatin receptor PET/CT using Ga-68-DOTA-conjugated peptides complements the diagnostic work-up in CUP syndromes with neuroendocrine tumours.

Schlüsselwörter

CUP-Syndrom - PET/CT - FDG - Somatostatin receptor ­imaging

Key words

Cancer of unknown primary sites - PET/CT - FDG - Somatostatin receptor imaging

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