Abstract
This study evaluated the stretching and dilatation of venous segments ex vivo in subjects
with primary varicose veins in comparison with comparable segments from subjects that
used the supplement Pycnogenol (150 mg/d) for 3 months before surgery. Subjects with
varicose veins and chronic venous insufficiency voluntarily used Pycnogenol for a
period of at least 3 months. The segments of veins removed with surgery (in 30 subjects
that had used Pycnogenol and in 10 comparable control subjects that had not used the
supplement) were compared with normal, unused vein segments harvested for bypass grafting.
The segments were suspended and a weight was attached to the distal part of the veins
for 3 minutes and dilated with pressurized water. Digital images were recorded; the
veins were measured before and after stretching to evaluate elongation. The manipulation
of the vein segment was minimal. Tests were completed within 20 minutes after harvesting
the veins. All segments were 4 cm long. The stretching test indicated a significantly
higher level of passive elongation in control, varicose segments (2.29; 0.65 mm) in
comparison with 1.39; 0.2 mm in vein segments from Pycnogenol-using patients. The
dilation test showed an average higher dilation (2.19; 0.3 mm) in control varicose
veins in comparison with varicose veins from Pycnogenol-using patients (1.32; 0.7
mm) (p < 0.05). Stretching and dilatation were lower in veins from Pycnogenol-using subjects
(p < 0.05). The measurement of destretching and the recovery after dilatation indicated
a better tone and recovery of the original size/shape in varicose segments from patients
using Pycnogenol. Varicose segments had a more significant persistent dilatation and
elongation in comparison with normal vein segments. Pycnogenol seems to decrease passive
dilatation and stretching and gives vein walls a greater tonic recovery and elasticity
that allows the vein to recover its original shape after dynamic stresses.
Keywords
Pycnogenol - chronic venous insufficiency - venous tone - varicose veins
