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Drug Res (Stuttg) 2014; 64(11): 584-590
DOI: 10.1055/s-0033-1363655
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Synthesis and Antinociception Activity of New Substituted Phenothiazines and Ethylenediamines as Antihistaminic Drugs

A. Ahmadi
1   Department of Chemistry, Faculty of Science, Karaj Branch, Islamic Azad University, Karaj, Iran
,
N. Naderi
2   School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
,
M. Souri
1   Department of Chemistry, Faculty of Science, Karaj Branch, Islamic Azad University, Karaj, Iran
,
F. Shirkavand
3   Department of Chemistry, Faculty of Science, Islamic Azad University, Shahre Ray Branch, Tehran, Iran
,
B. Nahri-Niknafs
1   Department of Chemistry, Faculty of Science, Karaj Branch, Islamic Azad University, Karaj, Iran
› Author Affiliations
Further Information

Publication History

received 21 November 2013

accepted 02 December 2013

Publication Date:
20 January 2014 (online)

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Abstract

Antihistamines play an important role in medicine when it comes to relieving seasonal or non-seasonal rhinitis, the common cold, and itching. They have also shown many various combinations of pharmacological properties such as anti-inflammatory and analgesic activities. Phenothiazines and ethylenediamines are 2 important classes of antihistamines with analgesic activities in addition to other pharmacological effects. In this study, some new derivatives of these compounds (V–IX) were synthesized and their antinociceptive behaviors were examined by pharmacological tests. The results indicated that new analogue with methyl groups produced a better analgesic activity than chlorine atoms but less than III (without any substitutions) in ethylenediamine class. Also in phenothiazine class, adding pyrimidine and pyridine substituted showed the better analgesic activity compared to other groups. Moreover, the analgesic activities proved that dimethylamine is the best group in amino alkyl side chain of these molecules relative to the substituted piperazines in new analogues.

Key words

antihistamines - phenothiazines - ethylenediamines - antinociceptive behaviors - writhing test - formalin test
 

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