SABCS 2013 – Neue Datenlage zum primär metastasierten Mammakarzinom

Die Fragestellung zur operativen Entfernung eines Primarius beim primär metastasierten Mammakarzinom war bis dato nur in retrospektiven Analysen untersucht. Auf dem letzten Breast Cancer Symposium in San Antonio (10-14.12.2013) wurde eine Reihe der neuen Arbeiten zu diesem wenig erforschten Krankheitsbild vorgestellt.

• Literatur

• 1 Sant M. Difference in stage and therapy for breast cancer across Europa. Int J Cancer 2001; 93: 894-901
• 2 Barinoff J, Hils R, Bender A et al. Clinicopathological differences between breast cancer in patients with primary metastatic disease and those without: A multicentre study. Eur J Cancer 2012; Aug 30
• 3 Andre F, Slimane K, Bacjelot T et al. Breast cancer with synchronous metastases: trend in survival during a 14-year period. J Clin Oncol 2004; 22: 3302-3308
• 4 Gelmon KA, Boyle F, Kaufman B et al. Open-label phase III randomized controlled trial comparing taxane-based chemotherapy (Tax) with lapatinib (L) or trastuzumab (T) as first-line therapy for women with HER2+ metastatic breast cancer: Interim analysis (IA) of NCIC CTG MA. 31/GSK EGF 108 919. 2012 ASCO Annual Meeting. Oral Abstract Session, Breast Cancer – HER2/ER. Abstract No: LBA671.
• 5 www.ago-online.de/de/fuer-mediziner/leitlinien/mamma/
• 6 Nguyen DH, Truong PT, Alexander T et al. Can locoregional treatment of the primary tumor improve outcomes for women with stage IV breast cancer at diagnosis?. Int J Radiat Oncol Biol Phys. 01.09.2012; 84 (1) 39-45 DOI: 10. 1016/j.ijrobp. 2011. 11. 046. Epub 2012 Feb 11
• 7 Ruiterkamp J, Ernst MF, van de Poll-Franse LV et al. Surgical resection of the primary tumor is associated with improved survival in patients with distant metastatic breast cnacer at diagnosis. Eur J Surg Oncol 2009; 35: 1146-1151
• 8 Rapiti E, Verkooilen HM, Vlastos G et al. Complete excision of primary breast tumor improves survival of patients with metastatic breast cancer at diagnosis. J Clin Oncol 2006; 24: 2743-2749
• 9 Gnerlich J, Jeffe DB, Deshpande AD et al. Surgical removal oft he primary tumor increases overall survival in patients with metastatic breast cancer. Analysis of the 1998–2003 SEER data. Ann Surg Oncol 2007; 14 (8) 2187-2194
• 10 Khan SA, Stewart AK, Morrow M. Does aggressive local therapy improve survival in metastatic breast cacner?. Surgery 2002; 132: 620-7
• 11 Badwe et al. Surgical removal of primary tumor and axillary lymph nodes in women with metastatic breast cacner at presentation: a randomized controlled trial. Abstr. S2–02; San Antonio Breast Cancer Symposium 2013
• 12 Soran et al. Early follow up of a randomized trial evaluation resection oft he primary breast tumor in women presenting with de novo stage IV breast cacner; Turkish Study Protocol MF07–01. Abstr. S2–03; San Antonio Breast Cancer Symposium 2013
• 13 Barinoff J, Schmidt M, Schneeweiss A et al. Difference in Survival among Women With Primary and Secondary Metastatic Breast Cance: Difference in Survival among Women With Primary and Secondary Metastatic Breast Cancer Abstr. P3-06–04; San Antonio Breast Cancer Symposium 2013.
• 14 Dawood S, Broglio K, Ensor GN et al. Survuval differences among women with de novo stage IV and relapsed breast cancer. Ann Oncol 2009; 21: 2169-74
• 15 Barinoff J, Heitz F, Kümmel S et al. Improvement of Survival in Patient with Primary Metastatic Breast Cancer over a 10-Year Periode: Prospective Analyses Based on Individual Patient Date from a Multicenter Data Bank. JCT, 2013, 4. Published Online October 2013( http://www.scirp.org/journal/jct )