Cinchona Alkaloids from Cinchona succirubra and Cinchona ledgeriana

Abstract

Seven new cinchona alkaloids, cinchonanines A–G (1–7), and 29 known alkaloids were isolated from the barks of Cinchona surrirubra and C. ledgeriana collected from Yunnan Province in China. The new structures were elucidated by extensive spectroscopic analysis. All compounds were evaluated for their cytotoxicity against five human cancer cell lines. Compounds 2, 13, 14, and 15 showed moderate cytotoxicity.

Key words

Cinchona surrirubra - Cinchona ledgeriana - Rubiaceae - cinchonanines A–G - cinchona alkaloids - cytotoxicity

• References

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